ArticleAnnals of biomedical engineering2006
Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate, and hydrogen ion.
Article in Annals of biomedical engineering, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 75 citations in OpenAlex.
- Modelling lung and muscle oxygen diffusion capacities from sea-level to Mount Everest.Scientific reports · 2026Article
- Oxygen dissociation curve inflection point during incremental exercise: a trigger for the Bohr effect.Pflugers Archiv : European journal of physiology · 2025Article
- Computer model coupling hemodynamics and oxygen transport in the coronary capillary network: Pulsatile vs. non-pulsatile analysis.Computer methods and programs in biomedicine · 2025Article
- Intact carbonic acid is a viable protonating agent for biological bases.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Simulation of the Perfusion of Contrast Agent Used in Cardiac Magnetic Resonance: A Step Toward Non-invasive Cardiac Perfusion Quantification.Frontiers in physiology · 2019Article
- Integrative model of coronary flow in anatomically based vasculature under myogenic, shear, and metabolic regulation.The Journal of general physiology · 2018Article
- The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats.Journal of orthopaedic translation · 2016Article
- Simple accurate mathematical models of blood HbO2 and HbCO2 dissociation curves at varied physiological conditions: evaluation and comparison with other models.European journal of applied physiology · 2016Article
- The Bohr Effect Is Not a Likely Promoter of Renal Preglomerular Oxygen Shunting.Frontiers in physiology · 2016Article
- Modeling the Behavior of Red Blood Cells within the Caudal Vein Plexus of Zebrafish.Frontiers in physiology · 2016Article
- The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.Advances in experimental medicine and biology · 2016Article
- Distinct functional roles of cardiac mitochondrial subpopulations revealed by a 3D simulation model.Biophysical journal · 2015Article
- Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle.Scientific reports · 2015Article
- Extracellular hemoglobin: the case of a friend turned foe.Frontiers in physiology · 2015Review
- Myocardial necrosis depth prediction during extracellular photosensitization reaction of talaporfin sodium by defined index using fluorescence measurement.Lasers in medical science · 2014Article
- Modeling serotonin uptake in the lung shows endothelial transporters dominate over cleft permeation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Modeling to link regional myocardial work, metabolism and blood flows.Annals of biomedical engineering · 2012Review
- The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
- Consequences of hyperoxia and the toxicity of oxygen in the lung.Nursing research and practice · 2011Article
- A metabolic model of human erythrocytes: practical application of the E-Cell Simulation Environment.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A detailed nonlinear four-region (red blood cell, plasma, interstitial fluid, and parenchymal cell) axially distributed convection-diffusion-permeation-reaction-binding computational model is developed to study the simultaneous transport and exchange of oxygen (O2) and carbon dioxide (CO2) in the blood-tissue exchange system of the heart. Since the pH variation in blood and tissue influences the transport and exchange of O2 and CO2 (Bohr and Haldane effects), and since most CO2 is transported as HCO3(-) (bicarbonate) via the CO2 hydration (buffering) reaction, the transport and exchange of HCO3(-) and H+ are also simulated along with that of O2 and CO2. Furthermore, the model accounts for the competitive nonlinear binding of O2 and CO2 with the hemoglobin inside the red blood cells (nonlinear O2-CO2 interactions, Bohr and Haldane effects), and myoglobin-facilitated transport of O2 inside the parenchymal cells. The consumption of O2 through cytochrome-c oxidase reaction inside the parenchymal cells is based on Michaelis-Menten kinetics. The corresponding production of CO2 is determined by respiratory quotient (RQ), depending on the relative consumption of carbohydrate, protein, and fat. The model gives a physiologically realistic description of O2 transport and metabolism in the microcirculation of the heart. Furthermore, because model solutions for tracer transients and steady states can be computed highly efficiently, this model may be the preferred vehicle for routine data analysis where repetitive solutions and parameter optimization are required, as is the case in PET imaging for estimating myocardial O2 consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.