ArticleCurrent genetics2006
The laccase multi-gene family in Coprinopsis cinerea has seventeen different members that divide into two distinct subfamilies.
Article in Current genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 152 citations in OpenAlex.
- Decoding the distribution, structure-function-redox potential relationship and recent advances in fungal laccases: a systematic approach.Bioprocess and biosystems engineering · 2026Review
- Specific Phenylpropanoid Oligomerization in a Neutral Environment by the Recombinant Alkaline Laccase fromBiomolecules · 2025Article
- An apoptosis-inducing factor controls programmed cell death and laccase expression during fungal interactions.Applied microbiology and biotechnology · 2024Article
- Bifunctional Sesquiterpene/Diterpene Synthase Agr2 fromACS chemical biology · 2024Article
- Genome-wide analysis of the Pleurotus eryngii laccase gene (PeLac) family and functional identification of PeLac5.AMB Express · 2023Article
- Genome-wide study of Cerrena unicolor 87613 laccase gene family and their mode prediction in association with substrate oxidation.BMC genomics · 2023Article
- Comparative genomic analysis of five coprinoid mushrooms species.Functional & integrative genomics · 2023Article
- pH Distribution along Growing Fungal Hyphae at Microscale.Journal of fungi (Basel, Switzerland) · 2022Article
- Coprinopsis cinerea Uses Laccase Lcc9 as a Defense Strategy To Eliminate Oxidative Stress during Fungal-Fungal Interactions.Applied and environmental microbiology · 2022Article
- Improvement of laccase activity by silencing PacC in Ganoderma lucidum.World journal of microbiology & biotechnology · 2022Article
- Illuminate the hidden: in vivo mapping of microscale pH in the mycosphere using a novel whole-cell biosensor.ISME communications · 2021Article
- Alternative Splicing of Heat Shock Transcription Factor 2 Regulates the Expression of Laccase Gene Family in Response to Copper inApplied and environmental microbiology · 2021Article
- Discovery of two novel laccase-like multicopper oxidases from Pleurotus citrinopileatus and their application in phenolic oligomer synthesis.Biotechnology for biofuels · 2021Article
- Article
- Characterization of a Yellow Laccase fromJournal of fungi (Basel, Switzerland) · 2021Article
- Enzymatic Oxidation of Ca-Lignosulfonate and Kraft Lignin in Different Lignin-Laccase-Mediator-Systems and MDF Production.Frontiers in bioengineering and biotechnology · 2021Article
- Genes Identification, Molecular Docking and Dynamics Simulation Analysis of Laccases fromInternational journal of molecular sciences · 2020Article
- Enzyme Activity Profiles Produced on Wood and Straw by Four Fungi of Different Decay Strategies.Microorganisms · 2020Article
- Selection markers for transformation of the sequenced reference monokaryon Okayama 7/#130 and homokaryon AmutBmut ofFungal biology and biotechnology · 2020Article
- Article
3 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
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Abstract
Seventeen non-allelic laccase genes and one gene footprint are present in the genome of Coprinopsis cinerea. Two gene subfamilies were defined by intron positions and similarity of deduced gene products, one with 15 members (lcc1-lcc15) and one with 2 members (lcc16, lcc17). The first subfamily divides in the phylogenetic tree of deduced proteins into smaller clusters that probably reflect recent gene duplication events. Different laccase genes diverged from each other both by frequent synonymous and non-synonymous codon changes. Mainly synonymous codon changes accumulate in alleles, with up to 12% total codon differences between given pairs of alleles. Overexpression of the 17 laccase genes under the control of a constitutive promoter identified nine active enzymes from subfamily 1. All of these showed laccase activities with DMP (2,6-dimethoxy phenol) as substrate but only eight of them also with ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)]. Lcc16 and Lcc17 share certain sequence features with ferroxidases but enzyme assays failed to show such activity. Lcc15 is expected to be non-functional in laccase activity due to an internal deletion of about 150 amino acids. Transcripts were obtained from all genes but splice junctions for three genes were not congruent with translation into a functional protein.
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