SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2006
Growth factors and cytokines in the prevention and treatment of oral and gastrointestinal mucositis.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Pooled it
- Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines.Annals of oncology : official journal of the European Society for Medical Oncology · 2011Guideline
- Zinc supplementation in children and adolescents with acute leukemia.European journal of clinical nutrition · 2013Trial
- Impact of cryotherapy on incidence and severity of oral mucositis in hematopoietic stem cell transplantation: retrospective observational study.Scientific reports · 2025Observational
- Article
- Treatment of mucositis with combined 660- and 808-nm-wavelength low-level laser therapy reduced mucositis grade, pain, and use of analgesics: a parallel, single-blind, two-arm controlled study.Lasers in medical science · 2018Article
- A mucoadhesive thermosensitive hydrogel containing erythropoietin as a potential treatment in oral mucositis: in vitro and in vivo studies.Drug delivery and translational research · 2018Article
- A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis.Biomolecules & therapeutics · 2015Article
- Azilsartan reduced TNF-α and IL-1β levels, increased IL-10 levels and upregulated VEGF, FGF, KGF, and TGF-α in an oral mucositis model.PloS one · 2015Article
- Oral and dental considerations in pediatric leukemic patient.ISRN hematology · 2014Review
- Emerging evidence on the pathobiology of mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Review
- Emerging evidence on the pathobiology of mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Review
- The MASCC/ISOO Mucositis Guidelines Update: introduction to the first set of articles.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Article
- Long-term alterations of cytokines and growth factors expression in irradiated tissues and relation with histological severity scoring.PloS one · 2011Article
- Pro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis.Radiation oncology (London, England) · 2010Article
- Radiation induced oral mucositis.Indian journal of palliative care · 2009Article
- Management of oral mucositis in patients who have cancer.Dental clinics of North America · 2008Review
- The influence of palifermin (Kepivance) on oral mucositis and acute graft versus host disease in patients with hematological diseases undergoing hematopoietic stem cell transplant.Bone marrow transplantation · 2007Article
- Developing evidence-based guidelines for management of alimentary mucositis: process and pitfalls.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goals of workGrowth factors and cytokines may be useful in preventing chemotherapy (CT)- and radiotherapy (RT)-induced oral and gastrointestinal mucositis. Two systematic reviews of the medical literature on growth factors and cytokines for the amelioration of CT- and RT-induced mucositis throughout the alimentary tract were performed by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The aim of these evidence-based scientific reviews was to critically evaluate the literature and create evidence-based guidelines for the use of growth factors and cytokines in the prevention or treatment of CT- and RT-induced mucositis.
methodThe two reviews covered articles on clinical trials from January 1966 through May 2002 and preclinical studies from June 2002 through May 2005, respectively. The systematic review process was based on a well-established method for evaluating scientific literature. MAIN
resultsThe number of articles in the first review was 29. In the second review, 23 articles were evaluated, 14 preclinical and 9 clinical studies. It was concluded from the first review that there was no sufficient evidence to provide any recommendations for clinical practice guidelines regarding growth factors and cytokines. From the second review, a guideline could be presented recommending the use of recombinant human keratinocyte growth factor-1 (palifermin) to prevent oral mucositis in patients receiving high-dose CT and total body irradiation followed by stem cell transplantation for haematological malignancies. A guideline could also be provided suggesting that granulocyte macrophage colony-stimulating factor mouthwash not be used for the prevention of oral mucositis in the transplant setting with high-dose CT and autologous or allogeneic stem cell transplantation.
conclusionsThese systematic reviews have provided clarity and shown exciting new results. Further studies will provide new options for this debilitating side-effect of cancer therapy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.