ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Near simultaneous release of classical and peptide cotransmitters from chromaffin cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.Cell reports · 2024Article
- Exploring the Therapeutic Effect of Neurotrophins and Neuropeptides in Neurodegenerative Diseases: at a Glance.Molecular neurobiology · 2023Review
- Tuning the Size of Large Dense-Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid-Liquid Phase Separation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- The β-Hydroxybutyrate-GPR109A Receptor Regulates Fasting-induced Plasticity in the Mouse Adrenal Medulla.Endocrinology · 2022Article
- Neuromodulation Can Be Simple: Myoinhibitory Peptide, Contained in Dedicated Regulatory Pathways, Is the Only Neurally-Mediated Peptide Modulator of Stick Insect Leg Muscle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Amyloid beta peptides, locus coeruleus-norepinephrine system and dense core vesicles.Brain research · 2019Review
- Recurrent hypoglycemia inhibits the counterregulatory response by suppressing adrenal activity.The Journal of clinical investigation · 2018Article
- AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.Endocrinology · 2017Article
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Article
- Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The functional significance of synaptotagmin diversity in neuroendocrine secretion.Frontiers in endocrinology · 2013Review
- Neuropeptide y gates a stress-induced, long-lasting plasticity in the sympathetic nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Stress-induced changes in adrenal neuropeptide Y expression are regulated by a negative feedback loop.Journal of neurochemistry · 2013Article
- Neuropeptide transmission in brain circuits.Neuron · 2012Review
- Corelease of dopamine and GABA by a retinal dopaminergic neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit.Frontiers in neuroscience · 2012Article
- Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells.Molecular biology of the cell · 2011Article
- Pancreatic beta cells synthesize neuropeptide Y and can rapidly release peptide co-transmitters.PloS one · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Adrenal chromaffin cells are an important part of the neuroendocrine system and under stressful conditions release catecholamines into the blood, thus regulating many physiological processes. In addition to the catecholamines, chromaffin cells also synthesize a range of peptides, including neuropeptide Y. Although the catecholamines and peptides are both contained within dense core granules, whether they are copackaged is less clear. Here, I investigate whether a single dense core granule can be loaded with both types of transmitter molecules. Using amperometry and FMRFamide tagging, I simultaneously measure the secretion of the catecholamines and a neuropeptide from mouse chromaffin cells in vitro. I find that fusion of a single dense core granule releases both types of transmitters into the extracellular space. Significant amounts of peptide escape from a fusing granule in 1-2 ms: almost as rapidly as the catecholamines. This suggests that the kinetics of peptide secretion might not be as sluggish as sometimes thought.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.