ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02386475 (Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction), which is not on this map. Cited by 306 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Serotonin and Levodopa Functional Recovery in Patients With Cerebral Infarction
Who cites it
306 citing papers in PubMed, 2 syntheses or guidelines pooled it, 718 citations in OpenAlex.
- Growth Hormone and Brain Regeneration: Evidence from Clinical Studies in Dementia, Traumatic Brain Injury, and Stroke: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Hyperbaric oxygen in children with cerebral palsy: A systematic review of effectiveness and safety.PloS one · 2022Pooled it
- Trial
- Neuronal migration into injured tissue: mechanisms and therapeutic strategies for brain regeneration.Regenerative therapy · 2026Review
- Dynamic interactions with neuroblasts promote oligodendrocyte progenitor migration to injured cortex.iScience · 2026Article
- Regeneration of the mammalian brain: a relic of evolution?Stem cells (Dayton, Ohio) · 2026Review
- Tongqiao Huoxue Decoction (TQHXD) ameliorates ischaemic stroke in rats by promoting glycolysis enhancing neurogenesis and activating BDNF/AKT/CREB signalling pathway.Metabolic brain disease · 2026Article
- Routes of precursors' migration in remyelination.Brain : a journal of neurology · 2026Review
- Novel stem cell therapy for cerebral palsy using stem cells from human exfoliated deciduous teeth.Stem cell research & therapy · 2026Article
- Neuronal Axon Generation/Regeneration Regulated by Sulfated Glycans.Advances in experimental medicine and biology · 2026Review
- Mesenchymal stromal/stem cell-derived extracellular vesicles in brain disorders: mechanisms of repair and recovery.Frontiers in cellular neuroscience · 2026Review
- Article
- How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration: Shared Mechanisms Between Growth Cones of Migrating Neurons and Axons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Ectopic recruitment of neuroblasts in striatal myelin bundles and nucleus accumbens following AraC chemical lesion.Stem cell reports · 2025Article
- Article
- Dl-3-n-Butylphthalide Promotes Neurogenesis in Ischemic Stroke Mice Through Wnt/β-Catenin Signaling Activation and Neurotrophic Factor Production.Molecular neurobiology · 2025Article
- Enhanced Response of ZnO Nanorod-Based Flexible MEAs for Recording Ischemia-Induced Neural Activity in Acute Brain Slices.Nanomaterials (Basel, Switzerland) · 2025Article
- A mathematical model suggests collectivity and inconstancy enhance the efficiency of neuronal migration in the adult brain.PLoS computational biology · 2025Article
- TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment.Biomolecules · 2025Review
- Structural pathways related to the subventricular zone are decreased in volume with altered microstructure in young adult males with autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
246 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.