ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Intrinsic and functional differences among commissural interneurons during fictive locomotion and serotonergic modulation in the neonatal mouse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
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- Long-Term Cultures of Spinal Cord Interneurons.Frontiers in cellular neuroscience · 2022Article
- A dynamic role for dopamine receptors in the control of mammalian spinal networks.Scientific reports · 2020Article
- Adenosine AMolecular neurobiology · 2019Article
- The Alteration of Intrinsic Excitability and Synaptic Transmission in Lumbar Spinal Motor Neurons and Interneurons of Severe Spinal Muscular Atrophy Mice.Frontiers in cellular neuroscience · 2019Article
- Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions.Frontiers in physiology · 2018Review
- Left-right coordination from simple to extreme conditions during split-belt locomotion in the chronic spinal adult cat.The Journal of physiology · 2017Article
- Adult spinal V2a interneurons show increased excitability and serotonin-dependent bistability.Journal of neurophysiology · 2015Article
- Electrophysiological profiles of induced neurons converted directly from adult human fibroblasts indicate incomplete neuronal conversion.Cellular reprogramming · 2014Article
- 5-HT₂ and 5-HT₇ receptor agonists facilitate plantar stepping in chronic spinal rats through actions on different populations of spinal neurons.Frontiers in neural circuits · 2014Article
- Multiple monoaminergic modulation of posturo-locomotor network activity in the newborn rat spinal cord.Frontiers in neural circuits · 2014Article
- Removing sensory input disrupts spinal locomotor activity in the early postnatal period.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Functional subpopulations of V3 interneurons in the mature mouse spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Neuronal activity in the isolated mouse spinal cord during spontaneous deletions in fictive locomotion: insights into locomotor central pattern generator organization.The Journal of physiology · 2012Article
- Postnatal emergence of serotonin-induced plateau potentials in commissural interneurons of the mouse spinal cord.Journal of neurophysiology · 2012Article
- Serotonin modulates multiple calcium current subtypes in commissural interneurons of the neonatal mouse.Journal of neurophysiology · 2012Article
- Long-duration perforated patch recordings from spinal interneurons of adult mice.Journal of neurophysiology · 2011Article
- Neuromodulation and flexibility in Central Pattern Generator networks.Current opinion in neurobiology · 2011Review
- Serotonin influences locomotion in the nudibranch mollusc Melibe leonina.The Biological bulletin · 2011Article
- Synaptic patterning of left-right alternation in a computational model of the rodent hindlimb central pattern generator.Journal of computational neuroscience · 2011Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Commissural interneurons (CINs) send their axons across the midline to innervate contralateral targets and have been implicated in the coordination of left-right limb movements during locomotion. In the neonatal mouse spinal cord, we studied the firing properties and responses to serotonin (5-HT) of two classes of CINs: those whose axons turn caudally after crossing the midline (dCINs) and those whose axons bifurcate after crossing the midline (adCINs). During NMDA and 5-HT-induced locomotor-like activity, a majority of lumbar (L2) dCINs fired rhythmically with ventral root-recorded motor activity, although their firing phase was widely distributed throughout the locomotor cycle. In contrast, none of the adCINs fired rhythmically during fictive locomotion. We studied the baseline firing and membrane properties, and responses to current injection, in dCINs and adCINs that had been partially isolated by blockade of rapid synaptic transmission (with antagonists to glutamate, GABA, and glycine). No significant baseline differences were found between the cell types. In contrast, 5-HT significantly increased the excitability of the isolated dCINs by depolarizing the membrane potential, reducing the postspike afterhyperpolarization amplitude and decreasing the action potential threshold. None of these parameters were affected by 5-HT in adCINs. These results, together with our recent study of a third class of CINs, the aCINs whose axons ascend after crossing the midline (Zhong et al., 2006), suggest that dCINs and aCINs, but not adCINs, are excited by 5-HT and are rhythmically active during fictive locomotion. Thus, they may play important roles in the coordination of left-right movements during fictive locomotion.
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