ArticlePLoS biology2006
Excitatory and feed-forward inhibitory hippocampal synapses work synergistically as an adaptive filter of natural spike trains.
Article in PLoS biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90 citing papers in PubMed.
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- Cell Type-Dependent Short-Term Plasticity and Dopaminergic Modulation of Sensory Synapses onto Mouse Superficial Dorsal Horn Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Rapid astrocyte-dependent facilitation amplifies multi-vesicular release in hippocampal synapses.Cell reports · 2022Article
- Object Boundary Detection in Natural Images May Depend on "Incitatory" Cell-Cell Interactions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Behavioral Timescale Cooperativity and Competitive Synaptic Interactions Regulate the Induction of Complex Spike Burst-Dependent Long-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- rTg(TauFrontiers in synaptic neuroscience · 2022Article
- Presynaptic endoplasmic reticulum regulates short-term plasticity in hippocampal synapses.Communications biology · 2021Article
- SyNC, a Computationally Extensive and Realistic Neural Net to Identify Relative Impacts of Synaptopathy Mechanisms on Glutamatergic Neurons and Their Networks in Autism and Complex Neurological Disorders.Frontiers in cellular neuroscience · 2021Article
- A Slow Short-Term Depression at Purkinje to Deep Cerebellar Nuclear Neuron Synapses Supports Gain-Control and Linear Encoding over Second-Long Time Windows.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Modeling the Short-Term Dynamics ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval.Molecular psychiatry · 2020Article
- Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex.Science advances · 2020Article
30 more citing papers are in PubMed but not listed here.
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Abstract
Short-term synaptic plasticity (STP) is an important mechanism for modifying neural circuits during computation. Although STP is much studied, its role in the processing of complex natural spike patterns is unknown. Here we analyze the responses of excitatory and inhibitory hippocampal synapses to natural spike trains at near-physiological temperatures. Our results show that excitatory and inhibitory synapses express complementary sets of STP components that selectively change synaptic strength during epochs of high-frequency discharge associated with hippocampal place fields. In both types of synapses, synaptic strength rapidly alternates between a near-constant level during low activity and another near-constant, but elevated (for excitatory synapses) or reduced (for inhibitory synapses) level during high-frequency epochs. These history-dependent changes in synaptic strength are largely independent of the particular temporal pattern within the discharges, and occur concomitantly in the two types of synapses. When excitatory and feed-forward inhibitory synapses are co-activated within the hippocampal feed-forward circuit unit, the net effect of their complementary STP is an additional increase in the gain of excitatory synapses during high-frequency discharges via selective disinhibition. Thus, excitatory and feed-forward inhibitory hippocampal synapses in vitro act synergistically as an adaptive filter that operates in a switch-like manner and is selective for high-frequency epochs.
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