ReviewWorld journal of gastroenterology2006
Nervous and Neuroendocrine regulation of the pathophysiology of cholestasis and of biliary carcinogenesis.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Liver-nervous system axis: pathways, dysregulation, and translational perspectives.Journal of neuroinflammation · 2026Review
- Overview of endoscopic biliary stenting in malignant obstructive jaundice.World journal of gastrointestinal surgery · 2025Article
- Bile acid-mediated signaling in cholestatic liver diseases.Cell & bioscience · 2023Review
- Review
- Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.Clinics and research in hepatology and gastroenterology · 2018Review
- Adenylyl cyclases in the digestive system.Cellular signalling · 2014Review
- Pituitary protein 7B2 plasma levels in patients with liver disease: Comparisons with other hormones and neuropeptides.Oncology letters · 2013Article
- Dipeptidylpeptidase--IV, a key enzyme for the degradation of incretins and neuropeptides: activity and expression in the liver of lean and obese rats.European journal of histochemistry : EJH · 2012Article
- Involvement of cholangiocyte proliferation in biliary fibrosis.World journal of gastrointestinal pathophysiology · 2010Article
- Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2010Review
- Human gallbladder carcinoma: Role of neurotrophins, MIB-1, CD34 and CA15-3.European journal of histochemistry : EJH · 2010Article
- Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression.Liver international : official journal of the International Association for the Study of the Liver · 2009Article
- Genetic and molecular abnormalities in cholangiocarcinogenesis.Anticancer research · 2009Review
- Experimental obstructive cholestasis: the wound-like inflammatory liver response.Fibrogenesis & tissue repair · 2008Article
- Leptin enhances cholangiocarcinoma cell growth.Cancer research · 2008Article
- Mechanisms of biliary carcinogenesis and growth.World journal of gastroenterology · 2008Review
- JAK-STAT pathway in carcinogenesis: is it relevant to cholangiocarcinoma progression?World journal of gastroenterology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholangiocytes, the epithelial cells lining the biliary ducts, are the target cells in several liver diseases. Cholangiopathies and cholangiocarcinoma generate interest in many scientists since the genesis. The developing mechanisms, and the therapeutic tools of these diseases are still undefined. Several studies demonstrate that many hormones, neuropeptides and neurotransmitters regulate malignant and non-malignant cholangiocyte pathophysiology in the course of chronic biliary diseases. The aim of this review is to present the findings of several studies published in the recent years that contributed to clarifying the role of nervous and neuroendocrine regulation of the pathophysiologic events associated with cholestasis and cholangiocarcinoma development. This manuscript is organized into two parts. The first part offers an overview of the innervation of the liver and the origin of neuroendocrine hormones, neurotransmitters and neuropeptides affecting cholangiocyte function and metabolism. The first section also reviews the effects played by several neuroendocrine hormones and nervous system on cholangiocyte growth, survival and functional activity in the course of cholestasis. In the second section, we summarize the results of some studies describing the role of nervous system and neuroendocrine hormones in the regulation of malignant cholangiocyte growth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.