Evidence map›Paper›PMID 16773703›Full record

ReviewWorld journal of gastroenterology2006

Calcium signaling in cholangiocytes.

Noritaka Minagawa, Barbara-E Ehrlich, Michael-H Nathanson

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Calcium Signaling in Cholangiocytes: Methods, Mechanisms, and Effects.International journal of molecular sciences · 2018
    Review
  3. Article
  4. Article
  5. Review
  6. Physiology of cholangiocytes.Comprehensive Physiology · 2013
    Review
  7. Article
  8. Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes.World journal of gastrointestinal pathophysiology · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Noritaka MinagawaDepartment of Medicine Pharmacology, Yale University School of Medicine, 1 Gilbert Street, Room TAC S241D, New Haven, CT 06519, USA.
Barbara-E Ehrlich
Michael-H Nathanson
Yale University · US

Funding

Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI WAJAHAT Zafar MEHAL · 1986 to 2026
$31.1M
Translational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI BENNETT, ANTON M · 2001 to 2020
$25.6M
CALCIUM WAVES IN HEPATOCYTES--MECHANISMS AND EFFECTSR01DK045710 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 1999 to 2014
$5.7M
Regulation of cholangiocytes by InsP3 receptor isoformsR01DK061747 · NIDDK · YALE UNIVERSITY · PI EHRLICH, BARBARA E., NATHANSON, MICHAEL H · 2003 to 2012
$3.4M
BILE SECRETION AND INTRACELLULAR CA2+ SIGNALSR29DK045710 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 1995 to 1999
–
NIDDK NIH HHS DK34989NIDDK NIH HHS DK45710NIDDK NIH HHS DK57751NIDDK NIH HHS DK61747NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK045710NIDDK NIH HHS R01 DK061747
6 · The paper itself

Abstract

Cytosolic Ca2+ is an important second messenger in virtually every type of cell. Moreover, Ca2+ generally regulates multiple activities within individual cells. This article reviews the cellular machinery that is responsible for Ca2+ signaling in cholangiocytes. In addition, two Ca2+-mediated events in cholangiocytes are discussed: bicarbonate secretion and apoptosis. Finally, emerging evidence is reviewed that Ca2+ signaling is involved in the pathogenesis of diseases affecting the biliary tree and that Ca2+ signaling pathways can be manipulated to therapeutic advantage in the treatment of cholestatic disorders.

Indexed as

AnimalsApoptosisBicarbonatesBile Duct DiseasesBile DuctsBiliary TractCalciumCell ProliferationExocytosisHumansIntercellular Signaling Peptides and ProteinsSecond Messenger SystemsSignal TransductionBicarbonatesCalciumIntercellular Signaling Peptides and Proteins

Identifiers

PMID16773703
PMCPMC4087562
OpenAlexW1700029225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.