ArticleWorld journal of gastroenterology2006
Loss of heterozygosity and microsatellite instabilities of fragile histidine triad gene in gastric carcinoma.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Isolated brachioradialis metastasis of gastric adenocarcinoma after R0 resection.World journal of surgical oncology · 2021Review
- Detection of Loss of Heterozygosity in cfDNA of AdvancedInternational journal of molecular sciences · 2019Article
- Pathogenetic mechanisms in gastric cancer.World journal of gastroenterology · 2014Review
- Article
- Comparative features of colorectal and gastric cancers with microsatellite instability in Chinese patients.Journal of Zhejiang University. Science. B · 2010Article
- Role of BMP3 in progression of gastric carcinoma in Chinese people.World journal of gastroenterology · 2010Article
- Relationship between nm23H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients.World journal of gastroenterology · 2008Article
- A novel approach to simultaneously scan genes at fragile sites.BMC cancer · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo detect the loss of heterozygosity (LOH) and microsatellite instabi1ities (MSI) of fragile histidine triad (FHIT) gene in gastric carcinoma and to study their association with the clinical pathological characteristics of gastric carcinoma.
methodsLOH and MSI of FHIT gene were detected at four microsaterllite loci D3Sl3H, D3S4l03, D3Sl48l and D3S1234 using PCR in matched normal and cancerous tissues from 50 patients with primary gastric cancer.
resultsThe average frequency of LOH and MSI of FHIT gene in gastric cancer was 32.4% and 26.4% respectively. LOH and MSI of FHIT gene in gastric cancer had no association with histological, Borrmann, and Lauren's classification. LOH of FHIT gene in gastric cancer was related to invasive depth. The frequency of FHIT LOH in gastric cancer with serosa-penetration was obviously higher than that in gastric cancer without serosa-penetration (73.5% vs 37.5%, P < 0.05). MSI of FHIT gene in gastric cancer was associated with the lymph node metastasis. The frequency of MSI in gastric cancer without lymph node metastasis was significantly higher than that in gastric cancer with lymph node metastasis (66.7% vs 34.3%, P < 0.05).
conclusionLOH of FHIT gene is correlated with invasive depth of gastric carcinoma. MSI of FHIT gene is correlated with lymph node metastases. LOH and MSI of FHIT gene play an important role in carcinogenesis of gastric cancer.
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