Evidence map›Paper›PMID 16773694›Full record

Trial reportWorld journal of gastroenterology2006

N-acetylcysteine does not prevent post-endoscopic retrograde cholangiopancreatography hyperamylasemia and acute pancreatitis.

Janusz Milewski, Grazyna Rydzewska, Malgorzata Degowska, Maciej Kierzkiewicz, Andrzej Rydzewski

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. N-acetylcysteine for sepsis and systemic inflammatory response in adults.The Cochrane database of systematic reviews · 2012
    Pooled it
  5. Pooled it
  6. Dynamic thiol/disulphide homeostasis in acute pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018
    Trial
  7. N‑acetylcysteine for post-ERCP pancreatitis prophylaxis: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Prevention of Post-ERCP Pancreatitis.Gastroenterology research and practice · 2012
    Article
  17. Article
  18. Pharmacological approach to acute pancreatitis.World journal of gastroenterology · 2008
    Review
  19. New advances in acute pancreatitis.Current opinion in gastroenterology · 2007
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Janusz MilewskiDepartment of Internal Medicine and Gastroenterology, Central Clinical Hospital of Ministry of Internal Affairs, Warsaw, Poland.
Grazyna Rydzewska
Malgorzata Degowska
Maciej Kierzkiewicz
Andrzej Rydzewski
Central Clinical Hospital · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAcute pancreatitis (AP) is the most common and often severe complication of endoscopic retrograde cholangiopancreatography (ERCP). The early step in the pathogenesis of acute pancreatitis is probably the capillary endothelial injury mediated by oxygen-derived free radicals. N-acetylcysteine - a free radical scavenger may be potentially effective in preventing post-ERCP acute pancreatitis and it is also known that N-acetylcysteine (ACC) can reduce the severity of disease in experimental model of AP.

methodsOne hundred and six patients were randomly allocated to two groups. Fifty-five patients were given N-acetylcysteine (two 600 mg doses orally 24 and 12 h before ERCP and 600 mg was given iv, twice a day for two days after the ERCP). The control group consisted of 51 patients who were given iv. isotonic saline twice a day for two days after the ERCP. Serum and urine amylase activities were measured before ERCP and 8 and 24 h after the procedure. The primary outcome parameter was post-ERCP acute pancreatitis and the secondary outcome parameters were differences between groups in serum and urine amylase activity.

resultsThere were no significant differences in the rate of post-ERCP pancreatitis between two groups (10 patients overall, 4 in the ACC group and 6 in the control group). There were also no significant differences in baseline and post-ERCP serum and urine amylase activity between ACC group and control group.

conclusionN-acetylcysteine fails to demonstrate any significant preventive effect on post-ERCP pancreatitis, as well as on serum and urine amylase activity.

Indexed as

AcetylcysteineAcute DiseaseAmylasesCholangiopancreatography, Endoscopic RetrogradeEndothelium, VascularFemaleFree RadicalsFree Radical ScavengersHumansHyperamylasemiaMalePancreatitisRegression AnalysisSeverity of Illness IndexTreatment OutcomeAcetylcysteineAmylasesFree RadicalsFree Radical Scavengers

Identifiers

PMID16773694
PMCPMC4087470
OpenAlexW1502248524

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.