ReviewWorld journal of gastroenterology2006
Role of discs large homolog 5.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- MiR-4788 promotes NSCLC progression by targeting DLG5 to enhance mitochondrial function.Human genomics · 2026Article
- Cytoskeletal Organization and Cell Polarity in the Pathogenesis of Crohn's Disease.Clinical reviews in allergy & immunology · 2021Review
- β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation.Cancer cell international · 2019Article
- Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification ofClinical cancer research : an official journal of the American Association for Cancer Research · 2017Article
- DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.Genes & development · 2016Article
- Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5.Genes & development · 2015Article
- The genetic predisposition and the interplay of host genetics and gut microbiome in Crohn disease.Clinics in laboratory medicine · 2014Review
- DLG5 in cell polarity maintenance and cancer development.International journal of biological sciences · 2014Review
- Genetic variants associated with Crohn's disease.The application of clinical genetics · 2013Article
- Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients.BMC medical genetics · 2008Article
- The Crohn's disease susceptibility gene DLG5 as a member of the CARD interaction network.Journal of molecular medicine (Berlin, Germany) · 2008Article
- Article
- Investigation of association of the DLG5 gene with psoriatic arthritis.Annals of the rheumatic diseases · 2007Article
- Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.Journal of human genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2004, an association of genetic variation in the discs large homolog 5 (DLG5) gene with inflammatory bowel disease (IBD) was described in two large European study samples. The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease. This review aims to summarize the current state of knowledge and to place the reported findings in the context of current concepts of complex diseases. This includes aspects of statistical power, phenotype differences and genetic heterogeneity between different populations as well as gene-gene and gene-environment interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.