ArticleAmerican journal of human genetics2006
Trait components provide tools to dissect the genetic susceptibility of migraine.
Article in American journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Meta-analysis of genome-wide association for migraine in six population-based European cohorts.European journal of human genetics : EJHG · 2011Pooled it
- Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study.BMC neurology · 2026Article
- The Dawn and Advancement of the Knowledge of the Genetics of Migraine.Journal of clinical medicine · 2024Review
- Symptoms associated with headache in youth.Cephalalgia : an international journal of headache · 2023Article
- A Guide to Genome-Wide Association Study Design for Diabetic Retinopathy.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Association of Genetic Variants With Migraine Subclassified by Clinical Symptoms in Adult Females.Frontiers in neurology · 2020Article
- TRPM8 genetic variant is associated with chronic migraine and allodynia.The journal of headache and pain · 2019Article
- Closing the 'phenotype gap' in precision medicine: improving what we measure to understand complex disease mechanisms.Mammalian genome : official journal of the International Mammalian Genome Society · 2019Review
- Symptoms-Based Phenotypes Among Women With Dysmenorrhea: A Latent Class Analysis.Western journal of nursing research · 2018Article
- Migraine genetics: current findings and future lines of research.Neurogenetics · 2015Article
- Selectivity in genetic association with sub-classified migraine in women.PLoS genetics · 2014Article
- Studies on the pathophysiology and genetic basis of migraine.Current genomics · 2013Article
- Physical comorbidity of migraine and other headaches in US adolescents.The Journal of pediatrics · 2012Article
- Heritability and genome-wide linkage analysis of migraine in the genetic isolate of Norfolk Island.Gene · 2012Article
- Article
- Genetics of migraine in the age of genome-wide association studies.The journal of headache and pain · 2012Review
- Next-generation genome-wide association studies: time to focus on phenotype?Circulation. Cardiovascular genetics · 2011Article
- Identification of molecular genetic factors that influence migraine.Molecular genetics and genomics : MGG · 2011Review
- Headache-type adverse effects of NO donors: vasodilation and beyond.British journal of pharmacology · 2010Review
- A visual migraine aura locus maps to 9q21-q22.Neurology · 2010Article
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Authors and funding
15 authors at 9 institutions in 3 countries.
Funding
Abstract
The commonly used "end diagnosis" phenotype that is adopted in linkage and association studies of complex traits is likely to represent an oversimplified model of the genetic background of a disease. This is also likely to be the case for common types of migraine, for which no convincingly associated genetic variants have been reported. In headache disorders, most genetic studies have used end diagnoses of the International Headache Society (IHS) classification as phenotypes. Here, we introduce an alternative strategy; we use trait components--individual clinical symptoms of migraine--to determine affection status in genomewide linkage analyses of migraine-affected families. We identified linkage between several traits and markers on chromosome 4q24 (highest LOD score under locus heterogeneity [HLOD] 4.52), a locus we previously reported to be linked to the end diagnosis migraine with aura. The pulsation trait identified a novel locus on 17p13 (HLOD 4.65). Additionally, a trait combination phenotype (IHS full criteria) revealed a locus on 18q12 (HLOD 3.29), and the age at onset trait revealed a locus on 4q28 (HLOD 2.99). Furthermore, suggestive or nearly suggestive evidence of linkage to four additional loci was observed with the traits phonophobia (10q22) and aggravation by physical exercise (12q21, 15q14, and Xp21), and, interestingly, these loci have been linked to migraine in previous studies. Our findings suggest that the use of symptom components of migraine instead of the end diagnosis provides a useful tool in stratifying the sample for genetic studies.
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