ReviewThe Journal of membrane biology
Electromechanical models of the outer hair cell composite membrane.
Review in The Journal of membrane biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Piezoelectric Biomaterials for Osteochondral Tissue Engineering: Advances, Mechanisms, and Translational Prospects.Journal of functional biomaterials · 2026Review
- Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.The Journal of biological chemistry · 2026Article
- Rates of Mitochondrial Metabolism of Glucose, Amino Acids, and Fatty Acids by the HEI-OC1 Inner Ear Cell Line.Biology · 2025Article
- Flexoelectricity in Biological Materials and Its Potential Applications in Biomedical Research.Bioengineering (Basel, Switzerland) · 2025Review
- Rate-dependent cochlear outer hair cell force generation: Models and parameter estimation.Biophysical journal · 2024Article
- State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.Scientific reports · 2021Article
- Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function.Scientific reports · 2019Article
- 3D Ultrastructure of the Cochlear Outer Hair Cell Lateral Wall Revealed By Electron Tomography.Frontiers in cellular neuroscience · 2019Article
- Actuation of flexoelectric membranes in viscoelastic fluids with applications to outer hair cells.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2014Article
- Application of fluorescence resonance energy transfer in protein studies.Journal of molecular structure · 2014Article
- Membrane cholesterol strongly influences confined diffusion of prestin.Biophysical journal · 2012Article
- Effect of membrane mechanics on charge transfer by the membrane protein prestin.Biomechanics and modeling in mechanobiology · 2012Article
- Selective cell-surface labeling of the molecular motor protein prestin.Biochemical and biophysical research communications · 2011Article
- Voltage and frequency dependence of prestin-associated charge transfer.Journal of theoretical biology · 2009Article
- Lipid lateral mobility in cochlear outer hair cells: regional differences and regulation by cholesterol.Journal of the Association for Research in Otolaryngology : JARO · 2009Article
- Outer hair cell electromechanical properties in a nonlinear piezoelectric model.The Journal of the Acoustical Society of America · 2009Article
- Power efficiency of outer hair cell somatic electromotility.PLoS computational biology · 2009Article
- Amphipath-induced nanoscale changes in outer hair cell plasma membrane curvature.Biophysical journal · 2009Article
- Anion control of voltage sensing by the motor protein prestin in outer hair cells.Biophysical journal · 2008Article
- Controlled microaspiration for high-pressure freezing: a new method for ultrastructural preservation of fragile and sparse tissues for TEM and electron tomography.Journal of microscopy · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The outer hair cell (OHC) is an extremely specialized cell and its proper functioning is essential for normal mammalian hearing. This article reviews recent developments in theoretical modeling that have increased our knowledge of the operation of this fascinating cell. The earliest models aimed at capturing experimental observations on voltage-induced cellular length changes and capacitance were based on isotropic elasticity and a two-state Boltzmann function. Recent advances in modeling based on the thermodynamics of orthotropic electroelastic materials better capture the cell's voltage-dependent stiffness, capacitance, interaction with its environment and ability to generate force at high frequencies. While complete models are crucial, simpler continuum models can be derived that retain fidelity over small changes in transmembrane voltage and strains occurring in vivo. By its function in the cochlea, the OHC behaves like a piezoelectric-like actuator, and the main cellular features can be described by piezoelectric models. However, a finer characterization of the cell's composite wall requires understanding the local mechanical and electrical fields. One of the key questions is the relative contribution of the in-plane and bending modes of electromechanical strains and forces (moments). The latter mode is associated with the flexoelectric effect in curved membranes. New data, including a novel experiment with tethers pulled from the cell membrane, can help in estimating the role of different modes of electromechanical coupling. Despite considerable progress, many problems still confound modelers. Thus, this article will conclude with a discussion of unanswered questions and highlight directions for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.