ReviewThe Journal of membrane biology
Mechano-electrical transduction: new insights into old ideas.
Review in The Journal of membrane biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Spontaneous calcium transients in hair cell stereocilia.Scientific reports · 2025Article
- Physics of mechanotransduction by Piezo ion channels.The Journal of general physiology · 2022Review
- Unbalanced bidirectional radial stiffness gradients within the organ of Corti promoted by TRIOBP.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Differentiation of embryonic stem cells into a putative hair cell-progenitor cells via co-culture with HEI-OC1 cells.Scientific reports · 2021Article
- The Development of Cooperative Channels Explains the Maturation of Hair Cell's Mechanotransduction.Biophysical journal · 2019Article
- Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.Science advances · 2019Article
- Article
- Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effect of nicotine on the structure of cochlea of guinea pigs.Anatomy & cell biology · 2014Article
- A molecular level prototype for mechanoelectrical transducer in mammalian hair cells.Journal of computational neuroscience · 2013Article
- Cyclic nucleotide-gated channel α-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction.The Journal of biological chemistry · 2013Article
- Myosin-II-mediated directional migration of Dictyostelium cells in response to cyclic stretching of substratum.Biophysical journal · 2013Article
- Permeation properties of the hair cell mechanotransducer channel provide insight into its molecular structure.Journal of neurophysiology · 2012Article
- CNGA3 is expressed in inner ear hair cells and binds to an intracellular C-terminus domain of EMILIN1.The Biochemical journal · 2012Article
- Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity.PloS one · 2011Article
- Review series: The cell biology of hearing.The Journal of cell biology · 2010Review
- Tip links in hair cells: molecular composition and role in hearing loss.Current opinion in otolaryngology & head and neck surgery · 2009Review
- Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line.Hearing research · 2009Article
- Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments.Nature cell biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The gating-spring theory of hair cell mechanotransduction channel activation was first postulated over twenty years ago. The basic tenets of this hypothesis have been reaffirmed in hair cells from both auditory and vestibular systems and across species. In fact, the basic findings have been reproduced in every hair cell type tested. A great deal of information regarding the structural, mechanical, molecular and biophysical properties of the sensory hair bundle and the mechanotransducer channel has accumulated over the past twenty years. The goal of this review is to investigate new data, using the gating spring hypothesis as the framework for discussion. Mechanisms of channel gating are presented in reference to the need for a molecular gating spring or for tethering to the intra- or extracellular compartments. Dynamics of the sensory hair bundle and the presence of motor proteins are discussed in reference to passive contributions of the hair bundle to gating compliance. And finally, the molecular identity of the channel is discussed in reference to known intrinsic properties of the native transducer channel.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.