ArticlePediatric nephrology (Berlin, Germany)2006
Predictive factors of chronic kidney disease in primary focal segmental glomerulosclerosis.
Article in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Treatment of steroid-resistant nephrotic syndrome in children: new guidelines from KDIGO.Pediatric nephrology (Berlin, Germany) · 2013Guideline
- Clinical trial of focal segmental glomerulosclerosis in children and young adults.Kidney international · 2011Trial
- Clinical trials treating focal segmental glomerulosclerosis should measure patient quality of life.Kidney international · 2011Trial
- Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome-a randomized controlled multicentre trial by the Arbeitsgemeinschaft für Pädiatrische Nephrologie.Pediatric nephrology (Berlin, Germany) · 2008Trial
- Idiopathic nephrotic syndrome in Syrian children: clinicopathological spectrum, treatment, and outcomes.Pediatric nephrology (Berlin, Germany) · 2024Observational
- Clinical and histopathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults.Scientific reports · 2024Article
- Predictors of long-term outcomes in pediatric focal segmental glomerulosclerosis.Journal of nephrology · 2023Article
- Primary focal segmental glomerulosclerosis in children: epidemiology, clinical presentation and prognosis.La Tunisie medicale · 2023Article
- Efficacy and Safety of Immunosuppressive Therapy in Primary Focal Segmental Glomerulosclerosis: A Systematic Review and Meta-analysis.Kidney medicine · 2022Article
- Review
- Baseline characteristics and long-term outcomes of steroid-resistant nephrotic syndrome in children: impact of initial kidney histology.Pediatric nephrology (Berlin, Germany) · 2020Article
- Changing epidemiology of nephrotic syndrome in Nigerian children: A cross-sectional study.PloS one · 2020Article
- MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome.Pediatric research · 2019Article
- Exploring the Clinical and Genetic Spectrum of Steroid Resistant Nephrotic Syndrome: The PodoNet Registry.Frontiers in pediatrics · 2018Review
- Long-Term Outcome of Steroid-Resistant Nephrotic Syndrome in Children.Journal of the American Society of Nephrology : JASN · 2017Article
- Efficacy and safety of immunosuppressive medications for steroid-resistant nephrotic syndrome in children: a systematic review and network meta-analysis.Oncotarget · 2017Article
- Long-term outcome of idiopathic steroid-resistant nephrotic syndrome in children.Pediatric nephrology (Berlin, Germany) · 2016Article
- A predictive model of progressive chronic kidney disease in idiopathic nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2015Article
- Microscopic Haematuria and Clinical Outcomes in Patients With Stage 3-5 Nondiabetic Chronic Kidney Disease.Scientific reports · 2015Article
- Role of Myeloid-Derived Suppressor Cells in Glucocorticoid-Mediated Amelioration of FSGS.Journal of the American Society of Nephrology : JASN · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal histological features of focal segmental glomerulosclerosis (FSGS) are found in 75% of pediatric patients with steroid-resistant nephrotic syndrome. In order to evaluate the predictive factors of chronic kidney disease (CKD), we retrospectively reviewed the records of 110 children with biopsy-proven FSGS admitted between 1972 and 2004. Renal survival was analyzed by the Kaplan-Meier method and Cox's regression model. Two multivariate models were developed: (1) from the onset of symptoms to the occurrence of CKD and (2) from the time of renal biopsy to CKD. Mean follow-up time was 10 years [standard deviation ((SD) 5.5], and 24 patients (21.8%) progressed to CKD. At baseline, after adjustment three variables remained as independent predictors of CKD: age >6.5 years (RR=3.3, 95% CI=1.3-7.8), creatinine >1 mg/dl (RR=2.5, 95% CI=0.97-6.5), and non-response to steroids (RR=7.3, 95% CI=2.7-19.7). In a model with continuous variables only age and non-response to steroids were associated with CKD. At the time of renal biopsy, after adjustment two variables remained as independent predictors of CKD: hematuria (RR=3.0, 95% CI=1.2-7.3) and creatinine >0.8 mg/dl (RR=4.3, 95% CI=1.7-10.6). In a model with continuous variables four factors predicted CKD: age, creatinine, hematuria, and percentage of global sclerosis.
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