Evidence map›Paper›PMID 16773409›Full record

Trial reportPediatric nephrology (Berlin, Germany)2006

Effect of fosinopril in children with steroid-resistant idiopathic nephrotic syndrome.

Zhuwen Yi, Zhihui Li, Xiao-Chuan Wu, Qing-Nan He, Xi-Qiang Dang, Xiao-Jie He

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric nephrology (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Steroid-resistant nephrotic syndrome: past and current perspectives.Pediatric health, medicine and therapeutics · 2017
    Review
  15. The non-immunosuppressive management of childhood nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2016
    Review
  16. Review
  17. Review
  18. Profiling proteinuria in children after renal transplantation.Pediatric nephrology (Berlin, Germany) · 2009
    Article
  19. Therapies for steroid-resistant nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2008
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhuwen YiLaboratory of Pediatric Nephrology, Institute of Pediatrics, The Second Xiangya Hospital, Central South University & Hunan Province Clinical Center of Pediatric Nephrology, Changsha, Hunan, 410011, People's Republic of China. csuxyyzw@hotmail.com
Zhihui Li
Xiao-Chuan Wu
Qing-Nan He
Xi-Qiang Dang
Xiao-Jie He
Second Xiangya Hospital of Central South University · CNCentral South University · CNHunan Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to test if fosinopril reduces urinary protein excretion and alleviates renal tubular damage in normotensive children with steroid-resistant idiopathic nephrotic syndrome (SRINS). We also aimed to evaluate whether there are changes in steady-state blood pressure and serum concentrations of serum angiotensin-converting enzyme (ACE) and plasma renin activity or angiotensin II (AT-II) in children under this treatment. Forty-five normotensive patients with SRINS were randomly divided into two groups. Group I was treated with fosinopril and prednisone for 12 weeks, while group II was treated with prednisone alone for the same duration. The values of 24-h urinary protein excretion were 1.25+/-0.64 vs 2.52+/-0.56 g/24 h (P<0.05), 1.16+/-0.45 vs 2.42+/-0.24 g/24 h (P<0.05), and 1.10+/-0.41 vs 2.05+/-0.46 g/24 h (P<0.05) in group I and group II patients, respectively, at 4, 8, and 12 weeks. Patients in group I showed lower serum concentrations of urinary retinol-binding protein and beta(2)-microglobulin (P<0.01) at the end of the study, but the patients' blood pressure and components of the renin-angiotensin system (RAS) had no change during treatment. The result suggested that fosinopril significantly reduced proteinuria and alleviated renal tubular damage, but did not influence blood pressure and components of systemic RAS in normotensive children with SRINS.

Indexed as

Drug ResistanceAngiotensin-Converting Enzyme InhibitorsAngiotensin IIBlood PressureChildDrug Therapy, CombinationFemaleFosinoprilGlucocorticoidsHumansMaleNephrotic SyndromePeptidyl-Dipeptidase APrednisoloneProteinuriaReninACE protein, humanAngiotensin-Converting Enzyme InhibitorsAngiotensin IIFosinoprilGlucocorticoidsPeptidyl-Dipeptidase APrednisoloneRenin

Identifiers

PMID16773409
OpenAlexW2164586853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.