ArticleBlood2006
Schistosoma mansoni infection in eosinophil lineage-ablated mice.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 195 citations in OpenAlex.
- Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.The Journal of allergy and clinical immunology · 2008Trial
- Association of eosinophil levels with 30-day overall mortality in hospitalized patients with aspiration pneumonia.Scientific reports · 2026Article
- A major ecological niche of eosinophils in evolvingScience advances · 2025Article
- Impact of -20 C° cryopreservation on serum factors from schistosomiasis patients at different storage durations: insights into serum bio-banking.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Artemisitene shows superiority over artemisinin in preventing Schistosoma japonica-induced liver disease.Parasites & vectors · 2024Article
- Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis.PLoS pathogens · 2024Article
- Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection.Scientific reports · 2024Article
- Galectin-receptor interaction: a key player in liver fibrosis induced by Schistosoma japonicum infection.Parasites & vectors · 2024Article
- Contribution of parasite and host genotype to immunopathology of schistosome infections.Parasites & vectors · 2024Article
- Innate Type-2 Cytokines: From Immune Regulation to Therapeutic Targets.Immune network · 2024Review
- Contribution of parasite and host genotype to immunopathology of schistosome infections.bioRxiv : the preprint server for biology · 2024Article
- HGPRT and PNP: Recombinant Enzymes fromPathogens (Basel, Switzerland) · 2023Article
- Living without eosinophils: evidence from mouse and man.The European respiratory journal · 2023Review
- How to train your myeloid cells: a way forward for helminth vaccines?Frontiers in immunology · 2023Review
- Effects of Immunization with RecombinantPathogens (Basel, Switzerland) · 2023Article
- Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context.Microorganisms · 2022Review
- Eosinophils and eosinophilic immune dysfunction in health and disease.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Profile of T and B lymphocytes in individuals resistant to Schistosoma mansoni infection.Parasitology research · 2022Article
- Dynamics of Host Immune Response Development DuringFrontiers in immunology · 2022Article
- Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis.Frontiers in immunology · 2022Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
We explore the controversial issue of the role of eosinophils in host defense against helminthic parasites using the established Schistosoma mansoni infection model in 2 novel mouse models of eosinophil lineage ablation (DeltadblGATA and TgPHIL). No eosinophils were detected in bone marrow of infected DeltadblGATA or TgPHIL mice, despite the fact that serum IL-5 levels in these infected mice exceeded those in infected wild type by approximately 4-fold. Liver granulomata from infected DeltadblGATA and TgPHIL mice were likewise depleted of eosinophils compared with those from their respective wild types. No eosinophil-dependent differences in granuloma number, size, or fibrosis were detected at weeks 8 or 12 of infection, and differential accumulation of mast cells was observed among the DeltadblGATA mice only at week 12. Likewise, serum levels of liver transaminases, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) increased in all mice in response to S mansoni infection, with no eosinophil-dependent differences in hepatocellular damage observed. Finally, eosinophil ablation had no effect on worm burden or on egg deposition. Overall, our data indicate that eosinophil ablation has no impact on traditional measures of disease in the S mansoni infection model in mice. However, eosinophils may have unexplored immunomodulatory contributions to this disease process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.