Evidence map›Paper›PMID 16772543›Full record

ReviewNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition2006

The use of selected nutrition supplements and complementary and alternative medicine in liver disease.

A James Hanje, Brett Fortune, Ming Song, Daniell Hill, Craig McClain

Open access · greenAbstract readReview
In one paragraph

Review in Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Nutrition in Patients With Cirrhosis.Gastroenterology & hepatology · 2016
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Alcoholic liver disease and malnutrition.Alcoholism, clinical and experimental research · 2011
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A James HanjeDepartment of Medicine, The Ohio State University, Columbus, Ohio, USA.
Brett Fortune
Ming Song
Daniell Hill
Craig McClain
University of Louisville · USThe Ohio State University · US

Funding

Tumor Necrosis Factor and Alcoholic Liver DiseaseR37AA010762 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2001 to 2010
$3.6M
S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver DiseaseR01AA015970 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2005 to 2010
$2.0M
Mechanisms of S-adenosylmethionine in NASHR01DK071765 · NIDDK · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2005 to 2009
$1.5M
ALCOHOL LIVER DISEASE AND S-ADENOSYLMETHIONINER01AA010496 · NIAAA · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J · 1996 to 2005
$1.5M
Oral Antioxidant/Anticytokine Therapy for ALDR01AA014185 · NIAAA · UNIVERSITY OF LOUISVILLE · PI HILL, DANIELL B · 2002 to 2005
$1.4M
PROSTAGLANDIN THERAPY FOR ALCOHOLIC HEPATITISK24AA000297 · NIAAA · UNIVERSITY OF LOUISVILLE · PI HILL, DANIELL B · 2000 to 2004
$566k
NIAAA NIH HHS K24 AA000297NIAAA NIH HHS K24AA000297NIAAA NIH HHS R01 AA010496NIAAA NIH HHS R01AA010496NIAAA NIH HHS R01 AA014185NIAAA NIH HHS R01AA014185NIAAA NIH HHS R01 AA015970NIAAA NIH HHS R01AA015970NIAAA NIH HHS R37 AA010762NIAAA NIH HHS R37AA010762NIDDK NIH HHS R01 DK071765NIDDK NIH HHS R01DK071765
6 · The paper itself

Abstract

Almost all patients with liver disease, especially advanced liver disease, have some evidence of malnutrition, including mineral/vitamin deficiency. A major health trend in the United States has been the significant growth in the use of complementary and alternative medicine (CAM), including nutrition supplements and herbal agents. In the 1990s, the United States government created the National Center for Complementary and Alternative Medicine (NCCAM), as well as the Office on Dietary Supplements, to extend our knowledge in these areas. CAM users are often highly educated and frequently use CAM therapy for chronic diseases, including chronic liver disease. Indeed, most studies suggest that patients with chronic liver disease frequently use nutrition supplements and CAM agents in addition to their traditional medicines. The purpose of this review is to provide an update on the role of nutrition supplements and herbals in liver disease. This article will focus mainly on 7 selected agents (vitamin E, zinc, magnesium, S-adenosylmethionine, betaine, silymarin, and glycyrrhizin), for which there have been not only in vitro and animal studies but also human clinical trials, and we will review both potential efficacy and safety issues.

Indexed as

Complementary TherapiesEvidence-Based MedicineHumansLiver DiseasesMalnutritionSafetyTreatment Outcome

Identifiers

PMID16772543
PMCPMC4239999
OpenAlexW1980287067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.