ArticleImmunology2006
Modulation of dendritic cell differentiation and cytokine secretion by the hydatid cyst fluid of Echinococcus granulosus.
Article in Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 56 citations in OpenAlex.
- Immunomodulatory effects of hydatid antigens on mesenchymal stem cells: gene expression alterations and functional consequences.Frontiers in microbiology · 2024Article
- Hydatid fluid fromFrontiers in cellular and infection microbiology · 2024Article
- Characterisation of extracellular vesicles isolated from hydatid cyst fluid and evaluation of immunomodulatory effects on human monocytes.Journal of cellular and molecular medicine · 2023Article
- Antigen B modulates anti-inflammatory cytokines in the EAE model of multiple sclerosis.Brain and behavior · 2023Article
- Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1Cancer immunology, immunotherapy : CII · 2021Article
- Modulation of the mTOR pathway plays a central role in dendritic cell functions after Echinococcus granulosus antigen recognition.Scientific reports · 2021Article
- Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway.Parasites & vectors · 2019Article
- Liver cystic echinococcosis and human host immune and autoimmune follow-up: A review.World journal of hepatology · 2017Review
- Factors Associated with Echinococcosis-Induced Perioperative Anaphylactic Shock.The Korean journal of parasitology · 2016Article
- Encephalitozoon intestinalis Inhibits Dendritic Cell Differentiation through an IL-6-Dependent Mechanism.Frontiers in cellular and infection microbiology · 2016Article
- Characterization of the inflammatory cell infiltrate and expression of costimulatory molecules in chronic echinococcus granulosus infection of the human liver.BMC infectious diseases · 2015Article
- Article
- Proteomic analysis of the excretory/secretory products and antigenic proteins of Echinococcus granulosus adult worms from infected dogs.BMC veterinary research · 2015Article
- Transcriptome profiles of the protoscoleces of Echinococcus granulosus reveal that excretory-secretory products are essential to metabolic adaptation.PLoS neglected tropical diseases · 2014Article
- Unconventional maturation of dendritic cells induced by particles from the laminated layer of larval Echinococcus granulosus.Infection and immunity · 2014Article
- Humoural immune response and pathological analysis in patients with false immune diagnosis of cystic echinococcosis.Parasite immunology · 2014Article
- Antitumor activity of human hydatid cyst fluid in a murine model of colon cancer.TheScientificWorldJournal · 2013Article
- Immunology and immunodiagnosis of cystic echinococcosis: an update.Clinical & developmental immunology · 2012Review
- Host-parasite relationship in cystic echinococcosis: an evolving story.Clinical & developmental immunology · 2012Review
- Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro.PLoS neglected tropical diseases · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic infection by Echinococcus granulosus results in establishment of fluid-filled cysts (hydatid cysts) in liver or lungs of infected hosts, which can escape destruction by the host immune system for long periods. This study explores the modulation by hydatid cyst fluid of the in vitro human monocyte to dendritic cell (DC) transition induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). Addition of the fluid to adherent peripheral blood monocytes cultured in GM-CSF/IL-4 stimulates release of prostaglandin E2 (PGE2) and IL-6. Exposure of differentiating DC to the fluid during the 7-day culture in GM-CSF/IL-4 impairs their subsequent ability to secrete IL-12, IL-6 or PGE2 in response to lipopolysaccharide (LPS) stimulation. This inhibition is not dependent on the initial release of PGE2. The presence of hydatid cyst fluid also modulates the phenotype of the cells generated during culture, resulting in increased CD14 expression and decreased expression of CD1a. Finally, hydatid fluid can stimulate predifferentiated DC to mature, as evidenced by release of IL-12 and IL-6, and by up-regulation of class II major histocompatibility complex and CD86. The possible role of dendritic cell modulation in regulating the host immune response to hydatid cysts is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.