ReviewJournal of chemical ecology2006
Pharmacological perspectives on the detoxification of plant secondary metabolites: implications for ingestive behavior of herbivores.
Review in Journal of chemical ecology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Plant Secondary Metabolites as Rodent Repellents: a Systematic Review.Journal of chemical ecology · 2016Pooled it
- Influence of Plant Secondary Metabolites on intake, Detoxification Costs, and Microbial Communities in Deer.Journal of chemical ecology · 2026Article
- The deterrent effects of individual monoterpene odours on the dietary decisions of African elephants.Animal cognition · 2023Article
- The koala gut microbiome is largely unaffected by host translocation but rather influences host diet.Frontiers in microbiology · 2023Article
- Fundamental dietary specialisation explains differential use of resources within a koala population.Oecologia · 2021Article
- High-quality de novo assembly of the Eucommia ulmoides haploid genome provides new insights into evolution and rubber biosynthesis.Horticulture research · 2020Article
- Megaherbivore browsers vs. tannins: is being big enough?Oecologia · 2020Article
- Genetic evidence of widespread variation in ethanol metabolism among mammals: revisiting the 'myth' of natural intoxication.Biology letters · 2020Article
- Faecal inoculations alter the gastrointestinal microbiome and allow dietary expansion in a wild specialist herbivore, the koala.Animal microbiome · 2019Article
- Seasonal regulation of condensed tannin consumption by free-ranging goats in a semi-arid savanna.PloS one · 2018Article
- Intestinal Lymphatic Transport: an Overlooked Pathway for Understanding Absorption of Plant Secondary Compounds in Vertebrate Herbivores.Journal of chemical ecology · 2017Article
- Energetic costs and implications of the intake of plant secondary metabolites on digestive and renal morphology in two austral passerines.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- The Relative Concentrations of Nutrients and Toxins Dictate Feeding by a Vertebrate Browser, the Greater Glider Petauroides volans.PloS one · 2015Article
- The dilemma of foraging herbivores: dealing with food and fear.Oecologia · 2014Article
- A pharm-ecological perspective of terrestrial and aquatic plant-herbivore interactions.Journal of chemical ecology · 2013Review
- Transfer of orally administered terpenes in goat milk and cheese.Asian-Australasian journal of animal sciences · 2012Article
- Modeling the dynamics of woody plant-herbivore interactions with age-dependent toxicity.Journal of mathematical biology · 2012Article
- Mechanisms for eliminating monoterpenes of sagebrush by specialist and generalist rabbits.Journal of chemical ecology · 2012Article
- Inhibition of snowshoe hare succinate dehydrogenase activity as a mechanism of deterrence for papyriferic acid in birch.Journal of chemical ecology · 2011Article
- The detoxification limitation hypothesis: where did it come from and where is it going?Journal of chemical ecology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant secondary metabolites (PSMs) are a major constraint to the ingestion of food by folivorous and browsing herbivores. Understanding the way in which mammalian detoxification pathways are adapted to deal with PSMs is crucial to understanding how PSMs influence ingestive behavior of herbivores and hence their fitness and the impact that they have on vegetation. Pharmacological concepts can provide insights into the relationship between the absorption and metabolic fate of PSMs and ingestive behavior. Lipophilic PSMs will be absorbed into the bloodstream and must be removed fast enough to prevent their accumulation to toxic levels. Elimination depends on their metabolism, usually by cytochrome P450 enzymes, to more polar metabolites that can be excreted by the kidney. The concentration of PSM in blood (C) is a better measure of exposure to a toxin compared to the amount ingested because there can be great variability in the rate and degree of absorption from the gut. C rises and falls depending on the relative rates of absorption and elimination. These rates depend in part on metabolic and transport processes that are saturable and liable to inhibition and induction by PSMs, indicating that complex interactions are likely. Herbivores can use diet choice and the rate and amount of PSM consumption to prevent C from reaching a critical level that produces significant adverse effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.