ArticleJournal of molecular evolution2006
Highly conserved caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 81 citations in OpenAlex.
- Intrinsic apoptosis is evolutionarily divergent among metazoans.Evolution letters · 2024Article
- Synergistic and antagonistic interactions of oxybenzone and ocean acidification: new insight into vulnerable cellular processes in non-calcifying anthozoans.Frontiers in physiology · 2023Article
- Larval transcriptomic responses of a stony coral, Acropora tenuis, during initial contact with the native symbiont, Symbiodinium microadriaticum.Scientific reports · 2022Article
- Phylogenetic analysis of the caspase family in bivalves: implications for programmed cell death, immune response and development.BMC genomics · 2021Article
- Sea Anemones Responding to Sex Hormones, Oxybenzone, and Benzyl Butyl Phthalate: Transcriptional Profiling andFrontiers in genetics · 2021Article
- Diversity in the intrinsic apoptosis pathway of nematodes.Communications biology · 2020Article
- Functional conservation of the apoptotic machinery from coral to man: the diverse and complex Bcl-2 and caspase repertoires of Acropora millepora.BMC genomics · 2016Article
- Relative Contributions of Various Cellular Mechanisms to Loss of Algae during Cnidarian Bleaching.PloS one · 2016Article
- Evolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animals.BMC evolutionary biology · 2014Article
- KEGG orthology-based annotation of the predicted proteome of Acropora digitifera: ZoophyteBase - an open access and searchable database of a coral genome.BMC genomics · 2013Article
- Article
- Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.Oncogene · 2012Article
- A profile of an endosymbiont-enriched fraction of the coral Stylophora pistillata reveals proteins relevant to microbial-host interactions.Molecular & cellular proteomics : MCP · 2012Article
- Major cellular and physiological impacts of ocean acidification on a reef building coral.PloS one · 2012Article
- Apoptosis and the selective survival of host animals following thermal bleaching in zooxanthellate corals.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Regulation of apoptotic mediators reveals dynamic responses to thermal stress in the reef building coral Acropora millepora.PloS one · 2011Article
- Defining the tipping point: a complex cellular life/death balance in corals in response to stress.Scientific reports · 2011Article
- Regulation of apoptotic pathways by Stylophora pistillata (Anthozoa, Pocilloporidae) to survive thermal stress and bleaching.PloS one · 2011Article
- Regulation of the Apaf-1-caspase-9 apoptosome.Journal of cell science · 2010Review
- Caspases: evolutionary aspects of their functions in vertebrates.Journal of fish biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Key insight into the complexities of apoptosis may be gained from the study of its evolution in lower metazoans. In this study we describe two genes from a cnidarian, Aiptasia pallida, that are homologous to key genes in the apoptotic pathway from vertebrates. The first is a novel ancient caspase, acasp, that displays attributes of both initiator and executioner caspases and includes a caspase recruitment domain (CARD). The second, a Bcl-2 family member, abhp, contains a BH1 and BH2 domain and shares structural characteristics and phylogenetic affinity with a group of antiapoptotic Bcl-2s including A1 and Bcl-2L10. The breadth of occurrence of other invertebrate homologues across the phylogenetic trees of both genes suggests that the complexity of apoptotic pathways is an ancient trait that predates the evolution of vertebrates and higher invertebrates such as nematodes and flies. This paves the way for establishing new lower metazoan model systems for the study of apoptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.