ArticleHistochemistry and cell biology2006
Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Review
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- Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling.Cancer science · 2023Article
- Triptolide inhibits the progression of Glioblastoma U251 cellsFrontiers in oncology · 2023Article
- Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells.Cellular signalling · 2022Article
- Calcitonin-Receptor-Like Receptor Signaling Governs Intestinal Lymphatic Innervation and Lipid Uptake.ACS pharmacology & translational science · 2019Article
- Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells.Journal of visualized experiments : JoVE · 2019Article
- Emerging Roles for Lymphatics in Chronic Liver Disease.Frontiers in physiology · 2019Review
- The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and Lymphangiogenesis.Cellular and molecular gastroenterology and hepatology · 2016Review
- Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1.Lipids in health and disease · 2016Article
- The new era of the lymphatic system: no longer secondary to the blood vascular system.Cold Spring Harbor perspectives in medicine · 2012Review
- Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors.The American journal of surgical pathology · 2012Article
- Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential.Genes & development · 2011Article
- Directed hepatic differentiation from embryonic stem cells.Protein & cell · 2011Review
- A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development.Journal of vascular research · 2011Article
- The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions.Genes & development · 2010Article
- Prox1 Facilitates Transfected CHO Cell Proliferation through Activation of the AKT Signaling Pathway.International journal of biomedical science : IJBS · 2010Article
- Hepatoblast and mesenchymal cell-specific gene-expression in fetal rat liver and in cultured fetal rat liver cells.Histochemistry and cell biology · 2009Article
- Thy-1 is expressed in myofibroblasts but not found in hepatic stellate cells following liver injury.Histochemistry and cell biology · 2009Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to analyse the changes of Prospero-related homeobox 1 (Prox1) gene expression in rat liver under different experimental conditions of liver injury, regeneration and acute phase reaction, and to correlate it with that of markers for hepatoblasts, hepatocytes, cholangiocytes and oval cells. Gene expression was studied at RNA level by RT-PCR, and at protein level by immunohistochemistry. At embryonal stage of rat liver development (embryonal days (ED) 14-16) hepatoblasts were found to be Prox1(+)/Cytokeratin (CK) 19(+) and alpha-fetoprotein (AFP)(+), at this stage Prox1(-)/CK19(+)/AFP(-) small cells (early cholangiocytes?) were identified. In fetal liver (ED 18-22) hepatoblasts were Prox1(+)/CK19(-)/AFP(+). CK7(+) cholangiocytes were detected at this stage, and they were Prox1(-)/AFP(-). In the adult liver hepatocytes were Prox1(+)/CK19(-)/CK7(-)/AFP(-), cholangiocytes were CK19(+) and/or CK7(+) and AFP(-)/Prox1(-). In models of liver damage and regeneration Prox1 remained a stable marker of hepatocytes. After 2-acetyl-aminofluorene treatment with partial hepatectomy (AAF/PH) the amount of Prox1 specific transcripts was low in the liver, when CK19 and AFP gene expression was high, and at no time point AFP(+)/CK19(+ )"oval cells" were found to be Prox1(+). However, a few Prox1(+)/CK19(+) and a few Prox1(+)/CK7(+ )cells were identified in the liver of AAF/PH-animals, which may represent precursors of hepatocytes, or a precancerous state.
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