ArticleMolecular psychiatry2006
Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes.
Article in Molecular psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Systematic Review of Polygenic Gene-Environment Interaction in Tobacco, Alcohol, and Cannabis Use.Behavior genetics · 2019Pooled it
- Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions.The pharmacogenomics journal · 2011Trial
- Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation.Human molecular genetics · 2008Trial
- Bernard Lerer: recipient of the 2014 inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics).Omics : a journal of integrative biology · 2014Article
- Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study.Translational psychiatry · 2013Article
- Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.Substance abuse and rehabilitation · 2012Article
- Childhood adversity, serotonin transporter (5-HTTLPR) genotype, and risk for cigarette smoking and nicotine dependence in alcohol dependent adults.Drug and alcohol dependence · 2012Article
- HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes.American journal of epidemiology · 2012Article
- Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- HTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory.European journal of clinical pharmacology · 2010Review
- Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions.Molecular psychiatry · 2009Review
- Smoking as a product of gene-environment interaction.Upsala journal of medical sciences · 2009Article
- Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex.Genetic testing · 2008Article
- ADHD and smoking: from genes to brain to behavior.Annals of the New York Academy of Sciences · 2008Review
- Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case-control study.BMC medical genetics · 2008Article
- A community-based study of cigarette smoking behavior in relation to variation in three genes involved in dopamine metabolism: Catechol-O-methyltransferase (COMT), dopamine beta-hydroxylase (DBH) and monoamine oxidase-A (MAO-A).Preventive medicine · 2008Article
- Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies.Drug and alcohol dependence · 2008Article
- Genetics of nicotine dependence and pharmacotherapy.Biochemical pharmacology · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cigarette smoking is a complex behavioral phenotype to which environmental, psychological and genetic factors contribute. The purpose of this study was to investigate these multifactorial effects with a specific focus on young women and on genes that encode serotonin (5-HT) receptors and the 5-HT transporter. A case-control sample of female Israeli college students provided comprehensive background data and details of cigarette smoking and completed a battery of psychological instruments. They were divided into smoking initiators (SI, n=242) or non-initiators (NI, n=148); SI were further subdivided into high (HND, n=127) and low nicotine-dependent smokers (LND, n=115) on the basis of their scores on the Fagerstrom Tolerance Questionnaire (FTQ). Single-nucleotide polymorphisms (SNPs) in five serotonin receptor genes (HTR1A, HTR1B, HTR2A, HTR2C and HTR6) and the 5-HT transporter-linked polymorphic region (5-HTTLPR) were genotyped. In a logistic regression model for SI (chi2=117.90, P=1.6 x 10(-19), Nagelkerke R2=0.42), novelty seeking (odds ratio (OR)=1.134, P=0.00009) was a significant risk factor. A five SNP CACCC haplotype in HTR6 was a strong protective factor against SI (OR=0.26; P=0.007). The interaction of HTR6-C276T genotype and lifetime traumatic experience contributed strongly to the risk of SI (OR=13.88, P=0.0001). Specifically, subjects homozygous for the HTR6-C276T C allele showed significantly increased risk of SI if they had experienced trauma. Although significant (chi2=42.85, P=1.00 x 10(-7)), the best-fitting model for ND was less predictive than the model for SI (Nagelkerke R2=0.24). HTR1B-G861C GG genotype (OR=2.29, P=0.01) was a significant risk factor for HND. Further studies should consider the interactive contribution of life events and relevant gene variants to cigarette smoking and other complex behavioral traits.
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