ArticleNeurology2006
Classification of partial seizure symptoms in genetic studies of the epilepsies.
Article in Neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Familial aggregation of focal seizure semiology in the Epilepsy Phenome/Genome Project.Neurology · 2017Article
- EEG correlates of seizure freedom in genetic generalized epilepsies.Neurology. Clinical practice · 2017Article
- Identifying and Analyzing Novel Epilepsy-Related Genes Using Random Walk with Restart Algorithm.BioMed research international · 2017Article
- Auras in generalized epilepsy.Neurology · 2014Article
- What's at stake? Genetic information from the perspective of people with epilepsy and their family members.Social science & medicine (1982) · 2011Article
- ADAM23, a Gene Related to LGI1, Is Not Linked to Autosomal Dominant Lateral Temporal Epilepsy.Epilepsy research and treatment · 2011Article
- Evaluation of depression risk in LGI1 mutation carriers.Epilepsia · 2010Article
- Article
- The power of linkage analysis of a disease-related endophenotype using asymmetrically ascertained sib pairs.Computational statistics & data analysis · 2009Article
- Familial mesial temporal lobe epilepsy (FMTLE) : a clinical and genetic study of 15 Italian families.Journal of neurology · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo develop standardized definitions for classification of partial seizure symptoms for use in genetic research on the epilepsies, and evaluate inter-rater reliability of classifications based on these definitions.
methodsThe authors developed the Partial Seizure Symptom Definitions (PSSD), which include standardized definitions of 41 partial seizure symptoms within the sensory, autonomic, aphasic, psychic, and motor categories. Based on these definitions, two epileptologists independently classified partial seizures in 75 individuals from 34 families selected because one person had ictal auditory symptoms or aphasia. The data used for classification consisted of standardized diagnostic interviews with subjects and family informants, and medical records obtained from treating neurologists. Agreement was assessed by kappa.
resultsAgreement between the two neurologists using the PSSD was "substantial" or "almost perfect" for most symptom categories.
conclusionsUse of standardized definitions for classification of partial seizure symptoms such as those in the Partial Seizure Symptom Definitions should improve reliability and accuracy in future genetic studies of the epilepsies.
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