ArticleHormones and behavior2006
Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats.
Article in Hormones and behavior, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 72 citations in OpenAlex.
- The role of ovarian hormones in risk aversion in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Steroid receptor coactivator-1: integrating steroid hormone signals to regulate brain function and disease.Frontiers in neuroscience · 2026Review
- Steroid receptor coactivator-1: The central intermediator linking multiple signals and functions in the brain and spinal cord.Genes & diseases · 2022Review
- Steroid Receptor Coactivator 3 Regulates Synaptic Plasticity and Hippocampus-dependent Memory.Neuroscience bulletin · 2021Article
- Dopamine-induced interactions of female mouse hypothalamic proteins with progestin receptor-A in the absence of hormone.Journal of neuroendocrinology · 2020Article
- Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain.Endocrinology · 2020Review
- Scaffold attachment factor B: distribution and interaction with ERα in the rat brain.Histochemistry and cell biology · 2020Article
- Dose-dependent effects of the antiprogestin, RU486, on sexual behavior of naturally cycling Fischer rats.Behavioural brain research · 2015Article
- Oestradiol and diet modulate energy homeostasis and hypothalamic neurogenesis in the adult female mouse.Journal of neuroendocrinology · 2014Article
- Intriguing roles of hippocampus-synthesized 17β-estradiol in the modulation of hippocampal synaptic plasticity.Journal of molecular neuroscience : MN · 2014Review
- Nuclear receptor coactivators: regulators of steroid action in brain and behaviour.Journal of neuroendocrinology · 2013Review
- Modulation of testosterone-dependent male sexual behavior and the associated neuroplasticity.General and comparative endocrinology · 2013Article
- An antiprogestin, CDB4124, blocks progesterone's attenuation of the negative effects of a mild stress on sexual behavior.Behavioural brain research · 2013Article
- Convergence of multiple mechanisms of steroid hormone action.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2012Review
- Neural progestin receptors and female sexual behavior.Neuroendocrinology · 2012Review
- Progesterone signaling mechanisms in brain and behavior.Frontiers in endocrinology · 2012Article
- Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).Journal of neurochemistry · 2011Article
- Maternal programming of sexual attractivity in female Long Evans rats.Psychoneuroendocrinology · 2011Article
- Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones.Endocrinology · 2011Article
- Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain.Neuroendocrinology · 2011Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The ovarian hormones, estradiol (E) and progesterone (P) facilitate the expression of sexual behavior in female rats. E and P mediate many of these behavioral effects by binding to their respective intracellular receptors in specific brain regions. Nuclear receptor coactivators, including Steroid Receptor Coactivator-1 (SRC-1) and CREB Binding Protein (CBP), dramatically enhance ligand-dependent steroid receptor transcriptional activity in vitro. Previously, our lab has shown that SRC-1 and CBP modulate estrogen receptor (ER)-mediated induction of progestin receptor (PR) gene expression in the ventromedial nucleus of the hypothalamus (VMN) and hormone-dependent sexual receptivity in female rats. Female sexual behaviors can be activated by high doses of E alone in ovariectomized rats, and thus are believed to be ER-dependent. However, the full repertoire of female sexual behavior, in particular, proceptive behaviors such as hopping, darting and ear wiggling, are considered to be PR-dependent. In the present experiments, the function of SRC-1 and CBP in distinct ER- (Exp. 1) and PR- (Exp. 2) dependent aspects of female sexual behavior was investigated. In Exp. 1, infusion of antisense oligodeoxynucleotides to SRC-1 and CBP mRNA into the VMN decreased lordosis intensity in rats treated with E alone, suggesting that these coactivators modulate ER-mediated female sexual behavior. In Exp. 2, antisense to SRC-1 and CBP mRNA around the time of P administration reduced PR-dependent ear wiggling and hopping and darting. Taken together, these data suggest that SRC-1 and CBP modulate ER and PR action in brain and influence distinct aspects of hormone-dependent sexual behaviors. These findings support our previous studies and provide further evidence that SRC-1 and CBP function together to regulate ovarian hormone action in behaviorally-relevant brain regions.
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