ArticlePLoS medicine2006
Embryonic pig pancreatic tissue transplantation for the treatment of diabetes.
Article in PLoS medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters.International journal of molecular sciences · 2019Article
- Preconditioning allows engraftment of mouse and human embryonic lung cells, enabling lung repair in mice.Nature medicine · 2015Article
- From Beta cell replacement to beta cell regeneration: implications for antidiabetic therapy.Journal of diabetes science and technology · 2014Review
- Optimal pig donor selection in islet xenotransplantation: current status and future perspectives.Journal of Zhejiang University. Science. B · 2014Review
- Pig-islet xenotransplantation: recent progress and current perspectives.Frontiers in surgery · 2014Review
- Article
- Fetal pancreas as a source for islet transplantation: sweet promise and current challenges.Diabetes · 2013Article
- The sequence and analysis of a Chinese pig genome.GigaScience · 2012Article
- Xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs.Journal of transplantation · 2011Article
- Engraftment of insulin-producing cells from porcine islets in non-immune-suppressed rats or nonhuman primates transplanted previously with embryonic pig pancreas.Journal of transplantation · 2011Article
- Therapeutic window, a critical developmental stage for stem cell therapies.Current stem cell research & therapy · 2010Review
- Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in nonimmune-suppressed diabetic rats.The American journal of pathology · 2010Article
- Article
- Inorganic nanoporous membranes for immunoisolated cell-based drug delivery.Advances in experimental medicine and biology · 2010Review
- Article
- Xenotransplantation of pancreatic and kidney primordia-where do we stand?Transplant immunology · 2009Article
- Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.American journal of physiology. Endocrinology and metabolism · 2009Article
- Normalization of glucose post-transplantation into diabetic rats of pig pancreatic primordia preserved in vitro.Organogenesis · 2008Article
- Transplantation of renal primordia: renal organogenesis.Pediatric nephrology (Berlin, Germany) · 2007Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransplantation of embryonic pig pancreatic tissue as a source of insulin has been suggested for the cure of diabetes. However, previous limited clinical trials failed in their attempts to treat diabetic patients by transplantation of advanced gestational age porcine embryonic pancreas. In the present study we examined growth potential, functionality, and immunogenicity of pig embryonic pancreatic tissue harvested at different gestational ages. METHODS AND
findingsImplantation of embryonic pig pancreatic tissues of different gestational ages in SCID mice reveals that embryonic day 42 (E42) pig pancreas can enable a massive growth of pig islets for prolonged periods and restore normoglycemia in diabetic mice. Furthermore, both direct and indirect T cell rejection responses to the xenogeneic tissue demonstrated that E42 tissue, in comparison to E56 or later embryonic tissues, exhibits markedly reduced immunogenicity. Finally, fully immunocompetent diabetic mice grafted with the E42 pig pancreatic tissue and treated with an immunosuppression protocol comprising CTLA4-Ig and anti-CD40 ligand (anti-CD40L) attained normal blood glucose levels, eliminating the need for insulin.
conclusionsThese results emphasize the importance of selecting embryonic tissue of the correct gestational age for optimal growth and function and for reduced immunogenicity, and provide a proof of principle for the therapeutic potential of E42 embryonic pig pancreatic tissue transplantation in diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.