ArticleHuman brain mapping2007
Odor processing in multiple chemical sensitivity.
Article in Human brain mapping, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS).International journal of environmental research and public health · 2021Pooled it
- Perspectives on multisensory perception disruption in idiopathic environmental intolerance: a systematic review.International archives of occupational and environmental health · 2018Pooled it
- Multiple Chemical Sensitivity: Review of the State of the Art in Epidemiology, Diagnosis, and Future Perspectives.Journal of occupational and environmental medicine · 2018Pooled it
- Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity.International archives of occupational and environmental health · 2016Trial
- Trial
- Comparison of volatile aroma compounds and consumer perception between domestic and imported milk in Korea.Food science of animal resources · 2026Article
- Multiple Chemical Sensitivity and the SLC Gene Superfamily: A Case-Control Study.International journal of molecular sciences · 2025Article
- Multiple Chemical Sensitivity: an Italian prevalence multicentric survey.Frontiers in public health · 2025Article
- Multiple Chemical Sensitivity: A Clinical Perspective.Brain sciences · 2024Review
- Combined Neurological Syndrome in Electrohypersensitivity and Multiple Chemical Sensitivity: A Clinical Study of 2018 Cases.Journal of clinical medicine · 2023Article
- Classification of odors associated with migraine attacks: a cross-sectional study.Scientific reports · 2023Article
- The neural substrates responsible for food odor processing: an activation likelihood estimation meta-analysis.Frontiers in neuroscience · 2023Article
- Review
- Motor Cortex Response to Pleasant Odor Perception and Imagery: The Differential Role of Personality Dimensions and Imagery Ability.Frontiers in human neuroscience · 2022Article
- Multiple Chemical Sensitivity Syndrome: A Principal Component Analysis of Symptoms.International journal of environmental research and public health · 2020Article
- Fully Printed Geranium-Inspired Encapsulated Arrays for Quantitative Odor Releasing.ACS omega · 2019Article
- Chemical intolerance: involvement of brain function and networks after exposure to extrinsic stimuli perceived as hazardous.Environmental health and preventive medicine · 2019Review
- Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session.BMJ open · 2017Article
- Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity.International archives of occupational and environmental health · 2017Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple chemical sensitivity (MCS) is characterized by somatic distress upon exposure to odors. As in other idiopathic environmental intolerances, the mechanisms behind the reported hypersensitivity are unknown. Using the advantage of the well-defined trigger (odor), we investigated whether subjects with MCS could have an increased odor-signal response in the odor-processing neuronal circuits. Positron emission tomography (PET) activation studies with several different odorants were carried out in 12 MCS females and 12 female controls. Activation was defined as a significant increase in regional cerebral blood flow (rCBF) during smelling of the respective odorant compared to smelling of odorless air. The study also included online measurements of respiratory frequency and amplitude and heart rate variations by recording of R wave intervals (RR) on the surface electrocardiogram. The MCS subjects activated odor-processing brain regions less than controls, despite the reported, and physiologically indicated (decreased RR interval) distress. In parallel, they showed an odorant-related increase in activation of the anterior cingulate cortex and cuneus-precuneus. Notably, the baseline rCBF was normal. Thus, the abnormal patterns were observed only in response to odor signals. Subjects with MCS process odors differently from controls, however, without signs of neuronal sensitization. One possible explanation for the observed pattern of activation in MCS is a top-down regulation of odor-response via cingulate cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.