ReviewPflugers Archiv : European journal of physiology2006
Heart failure: a model of cardiac and skeletal muscle energetic failure.
Review in Pflugers Archiv : European journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 69 citations in OpenAlex.
- Calcium ATPase (PMCA) and GLUT-4 Upregulation in the Transverse Tubule Membrane of Skeletal Muscle from a Rat Model of Chronic Heart Failure.International journal of molecular sciences · 2024Article
- Molecular mechanisms underlying sarcopenia in heart failure.The journal of cardiovascular aging · 2024Article
- Iron Deficiency and Deranged Myocardial Energetics in Heart Failure.International journal of environmental research and public health · 2022Review
- Treatment of Cheyne-Stokes Respiration in Heart Failure with Adaptive Servo-Ventilation: An Integrative Model.Advances in experimental medicine and biology · 2022Article
- Iron deficiency as an emerging therapeutic target in patients stabilized after an episode of acute heart failure.Cardiology journal · 2021Review
- Iron status, catabolic/anabolic balance, and skeletal muscle performance in men with heart failure with reduced ejection fraction.Cardiology journal · 2021Article
- High-fat diet affects skeletal muscle mitochondria comparable to pressure overload-induced heart failure.Journal of cellular and molecular medicine · 2020Article
- Article
- Skeletal muscle alterations in HFrEF vs. HFpEF.Current heart failure reports · 2017Review
- Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Adiponectin: key role and potential target to reverse energy wasting in chronic heart failure.Heart failure reviews · 2013Review
- Comparative differential proteomic profiles of nonfailing and failing hearts after in vivo thoracic aortic constriction in mice overexpressing FKBP12.6.Physiological reports · 2013Article
- Skeletal muscle protein metabolism in human heart failure.Current opinion in clinical nutrition and metabolic care · 2013Review
- Unraveling new mechanisms of exercise intolerance in chronic heart failure: role of exercise training.Heart failure reviews · 2013Review
- Skeletal muscle mitochondrial dysfunction precedes right ventricular impairment in experimental pulmonary hypertension.Molecular and cellular biochemistry · 2013Article
- Skeletal muscle mitochondrial density, gene expression, and enzyme activities in human heart failure: minimal effects of the disease and resistance training.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.PloS one · 2011Article
- Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure.PloS one · 2011Article
- Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload.American journal of physiology. Heart and circulatory physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic heart failure (CHF), the new epidemic in cardiology, is characterized by energetic failure of both cardiac and skeletal muscles. The failing heart wastes energy due to anatomical changes that include cavity enlargement, altered geometry, tachycardia, mitral insufficiency and abnormal loading, while skeletal muscle undergoes atrophy. Cardiac and skeletal muscles also have altered high-energy phosphate production and handling in CHF. Nevertheless, there are differences in the phenotype of myocardial and skeletal muscle myopathy in CHF: cardiomyocytes have a lower mitochondrial oxidative capacity, abnormal substrate utilisation and intracellular signalling but a maintained oxidative profile; in skeletal muscle, by contrast, mitochondrial failure is less clear, and there is altered microvascular reactivity, fibre type shifts and abnormalities in the enzymatic systems involved in energy distribution. Underlying these phenotypic abnormalities are changes in gene regulation in both cardiac and skeletal muscle cells. Here, we review the latest advances in cardiac and skeletal muscle energetic research and argue that energetic failure could be taken as a unifying mechanism leading to contractile failure, ultimately resulting in skeletal muscle energetic failure, exertional fatigue and death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.