ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2006
Mapping of the loci controlling oleic and linolenic acid contents and development of fad2 and fad3 allele-specific markers in canola (Brassica napus L.).
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59 citing papers in PubMed, 174 citations in OpenAlex.
- Towards premium rapeseed oil: leveraging allelic variation in BnaFAD2.A5, BnaFAD3.A4 and BnaFAD3.C4 for molecular design breeding.BMC plant biology · 2026Article
- CRISPR/Cas9-Mediated Editing in FAD2 Gene to Enhance Oil Quality in Soybean [Glycine max (L.) Merrill].PloS one · 2026Article
- Genome-Wide Association Study for Markers Related to Protein, Fiber (ADF and NDF) and Oil Content in Winter Oilseed Rape Seeds (International journal of molecular sciences · 2025Article
- Identification of transcription factor BnHDG4-A08 as a novel candidate associated with the accumulation of oleic, linoleic, linolenic, and erucic acid in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Improving linolenic acid content in rapeseed oil by overexpression ofMolecular breeding : new strategies in plant improvement · 2024Article
- Generation of Sesame Mutant Population by Mutagenesis and Identification of High Oleate Mutants by GC Analysis.Plants (Basel, Switzerland) · 2023Article
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- CRISPR/Cas9-Mediated Gene Editing ofGenes · 2022Article
- CRISPR/Cas9-mediated editing of double loci ofFrontiers in plant science · 2022Article
- Strategy of Salt Tolerance and Interactive Impact ofPlants (Basel, Switzerland) · 2021Article
- Identification and Development of KASP Markers for Novel MutantFrontiers in plant science · 2021Article
- Cleaved amplified polymorphic sequences (CAPS) marker for identification of two mutant alleles of the rapeseed BnaA.FAD2 gene.Molecular biology reports · 2020Article
- Modifications of fatty acid profile through targeted mutation at BnaFAD2 gene with CRISPR/Cas9-mediated gene editing in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- GWAS and co-expression network combination uncovers multigenes with close linkage effects on the oleic acid content accumulation in Brassica napus.BMC genomics · 2020Article
- The impact of reducing fatty acid desaturation on the composition and thermal stability of rapeseed oil.Plant biotechnology journal · 2020Article
- Genetic manipulation of ABI3 confers frost-tolerant seed degreening in canola.Plant biotechnology journal · 2020Article
- Article
- Association Study of the 5'UTR Intron of theFrontiers in plant science · 2020Article
- A novel quantitative trait locus on chromosome A9 controlling oleic acid content in Brassica napus.Plant biotechnology journal · 2019Article
- Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quality of canola oil is determined by its constituent fatty acids such as oleic acid (C18:1), linoleic acid (C18:2) and linolenic acid (C18:3). Most canola cultivars normally produce oil with about 55-65% oleic acid and 8-12% linolenic acid. High concentrations of linolenic acid lead to oil instability and off-type flavor, while high levels of oleic acid increase oxidative stability and nutritional value of oil. Therefore, development of canola cultivars with increased oleic acid and reduced linolenic acid is highly desirable for canola oil quality. In this study, we have mapped one locus that has a major effect and one locus that has a minor effect for high oleic acid and two loci that have major effects for low linolenic acid in a doubled haploid population. The major locus for high C18:1 was proven to be the fatty acid desaturase-2 (fad2) gene and it is located on the linkage group N5; the minor locus is located on N1. One major QTL for C18:3 is the fatty acid desaturase-3 gene of the genome C (fad3c) and it is located on N14. The second major QTL resides on N4 and is the fad3a gene of the A genome. We have sequenced genomic clones of the fad2 and fad3c genes amplified from an EMS-induced mutant and a wild-type canola cultivar. A comparison of the mutant and wild-type allele sequences of the fad2 and fad3c genes revealed single nucleotide mutations in each of the genes. Detailed sequence analyses suggested mechanisms by which both the mutations can cause altered fatty acid content. Based on the sequence differences between the mutant and wild-type alleles, two single nucleotide polymorphism (SNP) markers, corresponding to the fad2 and fad3c gene mutations, were developed. These markers will be highly useful for direct selection of desirable fad2 and fad3c alleles during marker-assisted trait introgression and breeding of canola with high oleic and low linolenic acid.
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