ArticleProceedings of the National Academy of Sciences of the United States of America2006
A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- From TCR fundamental research to innovative chimeric antigen receptor design.Nature reviews. Immunology · 2025Review
- A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation.Biology · 2023Review
- Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding.International journal of molecular sciences · 2021Article
- Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor.eLife · 2019Article
- Transcriptome analysis reveals regional and temporal differences in mucosal immune system development in the small intestine of neonatal calves.BMC genomics · 2016Article
- Basal and antigen-induced exposure of the proline-rich sequence in CD3ε.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Autoimmunity and asthma: The dirt on the hygiene hypothesis.Self/nonself · 2010Article
- The SCHOOL of nature: I. Transmembrane signaling.Self/nonself · 2010Article
- Nck adapter proteins: functional versatility in T cells.Cell communication and signaling : CCS · 2009Article
- Central tolerance: what have we learned from mice?Seminars in immunopathology · 2008Review
- A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation.PloS one · 2008Article
- Activation outcomes induced in naïve CD8 T-cells by macrophages primed via "phagocytic" and nonphagocytic pathways.Molecular biology of the cell · 2008Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell antigen receptor (TCR) triggering determines the fate of immature thymocytes. The affinity of the TCR for its endogenous peptide/MHC ligands serves as a signal for positive or negative selection through mechanisms that are still little understood. We have used a conformation-specific antibody to demonstrate that recognition of TCR ligands that lead to negative selection induces a conformational change in the TCR in situ. In contrast, this conformational change is elicited in only a small percentage of immature thymocytes during positive selection. Using a TUNEL assay, we demonstrate that the conformational change in the TCR is strongly linked to activation of programmed cell death in conditions leading to negative selection. Furthermore, the few conformational change-positive thymocytes detected in conditions that preferably lead to positive selection are also TUNEL-positive. Thus, the conformational change in the TCR may underlie the discrimination of ligands leading to positive and negative selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.