ReviewNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2006
Biomarkers to assess the utility of potential reduced exposure tobacco products.
Review in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of heated tobacco products on biomarkers of potential harm and adverse events: a systematic review and meta-analysis.Tobacco control · 2026Pooled it
- Changes in biomarkers after 180 days of tobacco heating product use: a randomised trial.Internal and emergency medicine · 2021Trial
- Smoking cessation program with exercise improves cardiovascular disease biomarkers in sedentary women.Journal of women's health (2002) · 2011Trial
- A pilot randomized study of smokeless tobacco use among smokers not interested in quitting: changes in smoking behavior and readiness to quit.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2010Trial
- Nicotine gum for pregnant smokers: a randomized controlled trial.Obstetrics and gynecology · 2008Trial
- Nicotine pharmacokinetics and subjective effects of three potential reduced exposure products, moist snuff and nicotine lozenge.Tobacco control · 2007Trial
- Article
- Associations between biomarkers of nicotine/tobacco exposure and respiratory symptoms among adults who exclusively smoke cigarettes in the U.S.: Findings from the PATH Study Waves 1-4 (2013-2017).Addictive behaviors reports · 2023Article
- Changes in biomarkers of exposure and biomarkers of potential harm after 360 days in smokers who either continue to smoke, switch to a tobacco heating product or quit smoking.Internal and emergency medicine · 2022Article
- Biomarkers of Toxicant Exposure and Inflammation Among Women of Reproductive Age Who Use Electronic or Conventional Cigarettes.Journal of women's health (2002) · 2021Article
- PhenX: Host: Biobehavioral measures for tobacco regulatory research.Tobacco control · 2020Article
- Persistent alterations of gene expression profiling of human peripheral blood mononuclear cells from smokers.Molecular carcinogenesis · 2016Article
- A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Providing a Science Base for the Evaluation of Tobacco Products.Tobacco regulatory science · 2015Article
- Evaluation of health promotion programmes in severe mental illness: theory and practice.International journal of methods in psychiatric research · 2015Article
- Urinary biomarkers of smokers' exposure to tobacco smoke constituents in tobacco products assessment: a fit for purpose approach.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013Article
- Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013Review
- Feasibility of identifying the tobacco-related global metabolome in blood by UPLC-QTOF-MS.Journal of proteome research · 2013Article
- Tobacco and nicotine product testing.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Article
Corrections and comments
- Republished as
Authors and funding
5 authors.
Funding
Abstract
To date, we have no valid biomarkers that serve as proxies for tobacco-related disease to test potential reduced exposure products. This paper represents the deliberations of four workgroups that focused on four tobacco-related heath outcomes: Cancer, nonmalignant pulmonary disease, cardiovascular disease, and fetal toxicity. The goal of these workgroups was to identify biomarkers that offer some promise as measures of exposure or toxicity and ultimately may serve as indicators for future disease risk. Recommendations were based on the relationship of the biomarker to what is known about mechanisms of tobacco-related pathogenesis, the extent to which the biomarker differs among smokers and nonsmokers, and the sensitivity of the biomarker to changes in smoking status. Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area.
Indexed as
Identifiers
16766411What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.