ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2006
GENTEX, a general multiscale model for in vivo tissue exchanges and intraorgan metabolism.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Regulation of the glucose supply from capillary to tissue examined by developing a capillary model.The journal of physiological sciences : JPS · 2018Article
- Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.PLoS computational biology · 2015Article
- Comparison of blood flow models and acquisitions for quantitative myocardial perfusion estimation from dynamic CT.Physics in medicine and biology · 2014Article
- SBML and CellML translation in antimony and JSim.Bioinformatics (Oxford, England) · 2014Article
- Modeling serotonin uptake in the lung shows endothelial transporters dominate over cleft permeation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- JSim, an open-source modeling system for data analysis.F1000Research · 2013Article
- Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport.Journal of pharmacokinetics and pharmacodynamics · 2011Article
- Quantitative and qualitative analysis and interpretation of CT perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2010Review
- Multiscale modeling of metabolism, flows, and exchanges in heterogeneous organs.Annals of the New York Academy of Sciences · 2010Article
- Predictive Modeling and Integrative Physiology: The Physiome Projects.The open pacing, electrophysiology & therapy journal · 2010Article
- A metabolic model of human erythrocytes: practical application of the E-Cell Simulation Environment.Journal of biomedicine & biotechnology · 2010Article
- Microcirculation and the physiome projects.Microcirculation (New York, N.Y. : 1994) · 2008Review
- Linking cellular energetics to local flow regulation in the heart.Annals of the New York Academy of Sciences · 2008Article
- Error detection and unit conversion.IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology SocietyArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Endothelial cells lining myocardial capillaries not only impede transport of blood solutes to the contractile cells, but also take up and release substrates, competing with myocytes. Solutes permeating this barrier exhibit concentration gradients along the capillary. This paper introduces a generic model, GENTEX, to characterize blood-tissue exchanges. GENTEX is a whole organ model of the vascular network providing intraorgan flow heterogeneity and accounts for substrate transmembrane transport, binding and metabolism in erythrocytes, plasma, endothelial cells, interstitial space and cardiomyocytes. The model is tested here for the analysis of multiple tracer indicator dilution data on purine nucleoside metabolism in the isolated Krebs-Henseleit-perfused non-working hearts. It has been also used for analysing NMR contrast data for regional myocardial flows and for positron emission tomographic studies of cardiac receptor kinetics. The facilitating transporters, binding sites and enzymatic reactions are nonlinear elements and allow competition between substrates and a reaction sequence of up to five substrate-product reactions in a metabolic network. Strategies for application start with experiment designs incorporating inert reference tracers. For the estimation of endothelial and sarcolemmal permeability-surface area products and metabolism of the substrates and products, model solutions were optimized to fit the data from pairs of tracer injections (of either inosine or adenosine, plus the reference tracers) injected under the same circumstances a few minutes later. The results provide a self-consistent description of nucleoside metabolism in a beating well-perfused rabbit heart, and illustrate the power of the model to fit multiple datasets simultaneously.
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