ArticleNucleic acids research1991
A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Regulation of CDX4 gene transcription by HoxA9, HoxA10, the Mll-Ell oncogene and Shp2 during leukemogenesis.Oncogenesis · 2014Article
- The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells.The Journal of biological chemistry · 2013Article
- β-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells.The Journal of biological chemistry · 2012Article
- HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells.The Journal of biological chemistry · 2012Article
- HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells.The Journal of biological chemistry · 2011Article
- HoxA10 influences protein ubiquitination by activating transcription of ARIH2, the gene encoding Triad1.The Journal of biological chemistry · 2011Article
- HoxA10 regulates transcription of the gene encoding transforming growth factor beta2 (TGFbeta2) in myeloid cells.The Journal of biological chemistry · 2011Article
- HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.Molecular and cellular biology · 2007Article
- Article
- The HOX homeodomain proteins block CBP histone acetyltransferase activity.Molecular and cellular biology · 2001Article
- Review
- A differential screen for ligand-regulated genes: identification of HoxA10 as a target of vitamin D3 induction in myeloid leukemic cells.Molecular and cellular biology · 1998Article
- AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins.Molecular and cellular biology · 1997Article
- Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.The EMBO journal · 1997Article
- Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.Molecular and cellular biology · 1997Article
- Homeobox genes and male reproductive development.Journal of assisted reproduction and genetics · 1996Review
- Article
- The expression pattern of the murine Hoxa-10 gene and the sequence recognition of its homeodomain reveal specific properties of Abdominal B-like genes.Molecular and cellular biology · 1995Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
As part of a survey of the expression of homeobox-containing genes in human hematopoietic cells, we identified a novel gene (PL1) expressed only in cells of the myelomonocytic lineage (Shen et al., Proc. Natl. Acad. Sci, USA 86, 8536, 1989). On Northern gel analysis, major transcripts of 3.0 and 2.2 kb length are observed. Alternatively spliced homeobox-containing cDNAs, corresponding to the major transcripts, have been cloned from two myeloid leukemia cell libraries. The two cDNAs share the homeodomain and 3' flanking region but have unique 5' flanking regions. The longer transcript, would encode a 496 amino acid homeobox-containing protein, while the shorter message would encode a 94 amino acid homeobox-containing protein lacking the extended amino-terminal region. These two transcripts are differentially expressed in human leukemia cell lines. The larger transcript is exclusively expressed in cells with myelomonocytic features, while the smaller transcript is expressed in a variety of hematopoietic cell types. PL mRNA is also detectable in normal human bone marrow by RNAse protection. Neither transcript is expressed in uninduced teratocarcinoma cells or in the adult human tissues surveyed. The homeodomain is identical to the genomic sequence for Hox 1H, a newly identified member of the Hox 1 locus (Acampora et al. Nucl. Acids Res. 17, 10385, 1989). The PL1 gene was localized to chromosome 7 using chromosome specific blots and sublocalized to region pI4-21 by in situ hybridization of chromosomal spreads, confirming its location within the Hox 1 complex.
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