ArticleRetrovirology2006
Induction of the HIV-1 Tat co-factor cyclin T1 during monocyte differentiation is required for the regulated expression of a large portion of cellular mRNAs.
Article in Retrovirology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- IL-4 downregulates gap junction protein connexin 26 to promote HIV-1 infection in macrophages.mBio · 2025Article
- Monocytes across life span in HIV infection: lights and shadows.Current opinion in HIV and AIDS · 2025Review
- A Truncated Isoform of Cyclin T1 Could Contribute to the Non-Permissive HIV-1 Phenotype of U937 Promonocytic Cells.Viruses · 2024Article
- Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Epigenetic regulation of macrophages: from homeostasis maintenance to host defense.Cellular & molecular immunology · 2020Review
- CDK9 inhibition strategy defines distinct sets of target genes.BMC research notes · 2014Article
- Making a Short Story Long: Regulation of P-TEFb and HIV-1 Transcriptional Elongation in CD4+ T Lymphocytes and Macrophages.Biology · 2012Article
- Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.Journal of virology · 2012Article
- Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.Journal of cellular physiology · 2012Article
- Limited redundancy in genes regulated by Cyclin T2 and Cyclin T1.BMC research notes · 2011Article
- Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II.Journal of virology · 2010Article
- 55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.Biochemical and biophysical research communications · 2010Article
- The macrophage in HIV-1 infection: from activation to deactivation?Retrovirology · 2010Review
- Host hindrance to HIV-1 replication in monocytes and macrophages.Retrovirology · 2010Review
- Regulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.Retrovirology · 2009Review
- Cyclin T2 is essential for mouse embryogenesis.Molecular and cellular biology · 2009Article
- Transcriptional restriction of human immunodeficiency virus type 1 gene expression in undifferentiated primary monocytes.Journal of virology · 2009Article
- miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1.PLoS pathogens · 2009Article
- Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.The Journal of biological chemistry · 2008Article
- Cyclin T1-dependent genes in activated CD4 T and macrophage cell lines appear enriched in HIV-1 co-factors.PloS one · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundP-TEFb, a general RNA polymerase II elongation factor, is composed of CDK9 (cyclin-dependent kinase 9) as a catalytic unit and either cyclin T1, T2 or K as a regulatory subunit. The cyclin T1/P-TEFb complex is targeted by HIV to mediate Tat transactivation. Cyclin T1 protein expression is induced during early macrophage differentiation, suggesting a role in regulation of mRNA expression during the differentiation process. To study the functional significance of cyclin T1 induction during differentiation, we utilized the human Mono Mac 6 (MM6) monocytic cell line.
resultsWe found that cyclin T1 protein expression is induced by a post-transcriptional mechanism following PMA treatment of MM6 cells, similar to its induction in primary monocytes and macrophages. Also in agreement with findings in primary cells, cyclin T2a is present at relatively high levels in MM6 cells and is not induced by PMA. Although the knock-down of cyclin T1 in MM6 cells by shRNA inhibited HIV-1 Tat transactivation, MM6 cell growth was not affected by the depletion of cyclin T1. Using DNA microarray technology, we found that more than 20% of genes induced by PMA require cyclin T1 for their normal level of induction, and approximately 15% of genes repressed by PMA require cyclin T1 for their normal level of repression. Gene ontology analysis indicates that many of these cyclin T1-dependent genes are related to immune response and signal transduction.
conclusionThese results suggest that cyclin T1 serves a critical role in the program of macrophage differentiation, and this raises questions about the feasibility of cyclin T1 serving as an antiviral therapeutic target.
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