ArticleCellular and molecular neurobiology2006
Identification of genes regulated by chronic social stress in the rat dorsal raphe nucleus.
Article in Cellular and molecular neurobiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
- αFrontiers in pharmacology · 2020Review
- PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model.Translational psychiatry · 2019Article
- Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (Genes & nutrition · 2018Article
- Long Term Physiologic and Behavioural Effects of Housing Density and Environmental Resource Provision for Adult Male and Female Sprague Dawley Rats.Animals : an open access journal from MDPI · 2017Article
- Molecular Signatures of Psychosocial Stress and Cognition Are Modulated by Chronic Lithium Treatment.Schizophrenia bulletin · 2016Article
- Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- 5-HT1A/1B receptors as targets for optimizing pigmentary responses in C57BL/6 mouse skin to stress.PloS one · 2014Article
- Downregulation of serotonergic gene expression in the Raphe nuclei of the midbrain under chronic social defeat stress in male mice.Molecular neurobiology · 2013Article
- Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner.Journal of neurochemistry · 2012Article
- Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus.Psychopharmacology · 2012Article
- Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression.Psychoneuroendocrinology · 2012Article
- Chronic social defeat up-regulates expression of norepinephrine transporter in rat brains.Neurochemistry international · 2012Article
- Escalated or suppressed cocaine reward, tegmental BDNF, and accumbal dopamine caused by episodic versus continuous social stress in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development by environment interactions controlling tryptophan hydroxylase expression.Journal of chemical neuroanatomy · 2011Review
- Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective.Journal of chemical neuroanatomy · 2011Review
- Chronic social defeat downregulates the 5-HT1A receptor but not Freud-1 or NUDR in the rat prefrontal cortex.Neuroscience letters · 2010Article
- Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.Behavioral neuroscience · 2009Article
- Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake.Pharmacology & therapeutics · 2008Review
- Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants.Cellular and molecular neurobiology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Changes in the serotonergic (5-HT) system are suspected to play a role in stress-induced neuropathologies and neurochemical measures indicate that serotonergic neurons in the dorsal raphe nucleus (DRN) are activated during stress. In the present study we analyzed gene expression in the DRN after chronic social stress using subtractive cDNA hybridization. 2. In the resident intruder paradigm, male Wistar rats were chronically stressed by daily social defeat during 5 weeks, RNA was isolated from their DRN, cDNA was generated, and subtractive hybridization was performed to clone sequences that are differentially expressed in the stressed animals. 3. From the cDNA libraries that were obtained, we selected the following genes for quantitative Real-time PCR: Two genes related to neurotransmission (synaptosomal associated protein 25 and synaptic vesicle glycoprotein 2b), a glial gene presumptively supporting neuroplasticity (N-myc downstream-regulated gene 2), and a gene possibly related to stress-induced regulation of transcription (CREB binding protein). These four genes were upregulated after the chronic social stress. Quantitative Western blotting revealed increased expression of synaptosomal associated protein 25 and synaptic vesicle glycoprotein 2b. 4. Genes directly related to 5-HT neurotransmission were not contained in the cDNA libraries and quantitative Real-time PCR for the serotonin transporter, tryptophan hydroxylase 2 and the 5-HT(1A) autoreceptor confirmed that these genes are not differentially expressed after 5-weeks of daily social stress. 5. These data show that 5 weeks of daily social defeat lead to significant changes in expression of genes related to neurotransmission and neuroplasticity in the DRN, whereas expression of genes directly related to 5-HT neurotransmission is apparently normal after this period of chronic stress.
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