ArticleCellular and molecular neurobiology2006
Mitochondrial D-loop variation in Persian multiple sclerosis patients: K and A haplogroups as a risk factor!!
Article in Cellular and molecular neurobiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Review
- Stressed cybrids model demyelinated axons in multiple sclerosis.Metabolic brain disease · 2013Article
- Do haplogroups H and U act to increase the penetrance of Alzheimer's disease?Cellular and molecular neurobiology · 2007Article
- The Role of Mitochondria in AMD: Current Knowledge and Future Applications.Journal of ophthalmic & vision researchArticle
- Variants of Mitochondrial Genome and Risk of Multiple Sclerosis Development in Russians.Acta naturaeArticle
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
: Multiple Sclerosis (MS) is a multifocal demyelinating central nervous system disorder in which interplay between genes and the environment are supposed to be involved. Mitochondrial DNA (mtDNA) has the only non-coding regions at the displacement loop (D-loop) region that contains two hypervariable segments (HVS-I and HVS-II) with high polymorphism. mtDNA has already been fully sequenced and many subsequent publications have showed polymorphic sites, haplogroups and haplotypes. Haplogroups could have important implications to understand association between mutability of the mitochondrial genome and disease. To assess relationship between mtDNA haplogroups and MS, we have sequenced the mtDNA HVS-I in 54 MS patients and 100 control subjects. We have found that haplogroups A and K are significantly more abundant in MS patients (P=0.042 for haplogroup A and P=0.0005 for haplogroup K). Thus, these two haplogroups might act synergistically to increase the penetrance of MS disease.
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