ReviewInternational journal of biological sciences2006
Hox genes are not always Colinear.
Review in International journal of biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Anterior-posterior patterning in the chaetognath Spadella cephaloptera informs bilaterian nervous system and tail evolution.Communications biology · 2025Article
- First chromosome-level genome assembly of the colonial chordate model Botryllus schlosseri (Tunicata).GigaScience · 2025Article
- The functional evolution of collembolan Ubx on the regulation of abdominal appendage formation.Development genes and evolution · 2024Article
- Article
- Emerging questions on the mechanisms and dynamics of 3D genome evolution in spiralians.Briefings in functional genomics · 2023Review
- CRISPR/Cas9 and FLP-FRT mediated regulatory dissection of the BX-C of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Echiuran Hox genes provide new insights into the correspondence between Hox subcluster organization and collinearity pattern.Proceedings. Biological sciences · 2022Article
- Phylogenetic analysis of forkhead transcription factors in the Panarthropoda.Development genes and evolution · 2022Article
- Phenotypic regionalization of the vertebral column in the thorny skate Amblyraja radiata: Stability and variation.Journal of anatomy · 2022Article
- Annotation of Hox cluster and Hox cofactor genes in the Asian citrus psyllid,GigaByte (Hong Kong, China) · 2022Article
- Inferring Tunicate Relationships and the Evolution of the Tunicate Hox Cluster with the Genome of Corella inflata.Genome biology and evolution · 2020Article
- Hox gene expression during development of the phoronidEvoDevo · 2020Article
- Article
- Vertebrate hox temporal collinearity: does it exist and what is it's function?Cell cycle (Georgetown, Tex.) · 2019Review
- Two more Posterior Hox genes and Hox cluster dispersal in echinoderms.BMC evolutionary biology · 2018Article
- Staggered Hox expression is more widespread among molluscs than previously appreciated.Proceedings. Biological sciences · 2018Article
- Two Tier Hox Collinearity Mediates Vertebrate Axial Patterning.Frontiers in cell and developmental biology · 2018Article
- Clustered brachiopod Hox genes are not expressed collinearly and are associated with lophotrochozoan novelties.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanisms of Specificity for Hox Factor Activity.Journal of developmental biology · 2016Article
- TCF/Lef regulates the Gsx ParaHox gene in central nervous system development in chordates.BMC evolutionary biology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The deuterostomes are the clade of animals for which we have the most detailed understanding of Hox cluster organisation. With the Hox cluster of amphioxus (Branchiostoma floridae) we have the best prototypical, least derived Hox cluster for the group, whilst the urochordates present us with some of the most highly derived and disintegrated clusters. Combined with the detailed mechanistic understanding of vertebrate Hox regulation, the deuterostomes provide much of the most useful data for understanding Hox cluster evolution. Considering both the prototypical and derived deuterostome Hox clusters leads us to hypothesize that Temporal Colinearity is the main constraining force on Hox cluster organisation, but until we have a much deeper understanding of the mechanistic basis for this phenomenon, and know how widespread across the Bilateria the mechanism(s) is/are, then we cannot know how the Hox cluster of the last common bilaterian operated and what have been the major evolutionary forces operating upon the Hox gene cluster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.