Trial reportJournal of acquired immune deficiency syndromes (1999)2006
A 2-arm, randomized, controlled trial of a motivational interviewing-based intervention to improve adherence to antiretroviral therapy (ART) among patients failing or initiating ART.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 14 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 14 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Psychosocial interventions enhance HIV medication adherence: A systematic review and meta-analysis.Journal of health psychology · 2020Pooled it
- Psychosocial group interventions to improve psychological well-being in adults living with HIV.The Cochrane database of systematic reviews · 2017Pooled it
- Motivational Interviewing Improves Medication Adherence: a Systematic Review and Meta-analysis.Journal of general internal medicine · 2016Pooled it
- Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.AIDS and behavior · 2014Pooled it
- Interventions to increase medication adherence in African-American and Latino populations: a literature review.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2014Pooled it
- Informing the dosing of interventions in randomized trials.Contemporary clinical trials · 2012Pooled it
- Motivational interviewing for improving outcomes in youth living with HIV.The Cochrane database of systematic reviews · 2012Pooled it
- Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.Annals of internal medicine · 2012Guideline
- A mixed-methods approach to synthesizing evidence on mediators of intervention effects.Western journal of nursing research · 2011Pooled it
- Improving health outcomes for youth living with the human immunodeficiency virus: a multisite randomized trial of a motivational intervention targeting multiple risk behaviors.Archives of pediatrics & adolescent medicine · 2009Pooled it
- Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Pooled it
- A systematic review comparing antiretroviral adherence descriptive and intervention studies conducted in the USA.AIDS care · 2009Pooled it
- Guideline
- Patient-Centered Outcomes of Medication Adherence Interventions: Systematic Review and Meta-Analysis.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes ResearchPooled it
- Personal Approach to Treatment Choices for HIV (PATCH): Randomized Controlled Trial of a Brief Motivational Enhancement Intervention to Improve Medication Adherence in Persons with HIV.AIDS and behavior · 2020Trial
- Effects of Minimal Versus Intensive Intervention to Enhance Motivational Interviewing in HIV Care.AIDS and behavior · 2018Trial
- Randomized Controlled Trial of an Intervention to Maintain Suppression of HIV Viremia After Prison Release: The imPACT Trial.Journal of acquired immune deficiency syndromes (1999) · 2017Trial
- Individuals motivated to participate in adherence, care and treatment (imPACT): development of a multi-component intervention to help HIV-infected recently incarcerated individuals link and adhere to HIV care.BMC public health · 2016Trial
- Randomized evaluation and cost-effectiveness of HIV and sexual and reproductive health service referral and linkage models in Zambia.BMC public health · 2016Trial
- The effect of antidepressant treatment on HIV and depression outcomes: results from a randomized trial.AIDS (London, England) · 2015Trial
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
rationale and purposeMotivational interviewing (MI) is a counseling technique that has been used effectively to change a number of health-related behaviors. We sought to assess the impact on patients' antiretroviral therapy (ART) adherence of a multicomponent, MI-based ART adherence intervention compared with that of an HIV informational control program. STUDY
designTwo-arm, randomized, controlled trial. SAMPLE: One hundred forty adult HIV-infected patients attending a large, academic center infectious diseases clinic who were either failing or newly initiating an ART regimen. STUDY ENDPOINTS: (1) Mean adherence level (% of prescribed doses take in the prior month) at the week 12 visit, (2) change in mean adherence, (3) percentage of patients achieving >95% adherence in the third 4-week block, and (4) change in viral load. MAIN
findingsThe MI group's mean adherence improved by 4.5% compared with a decrease in the control group's adherence by 3.83% (P = 0.10). In the treatment group, 29% achieved >95% adherence compared with only 17% in the control group (P = 0.13). When we controlled for ethnicity, the intervention group had 2.75 times higher odds of achieving more than 95% adherence than did the controls (P = 0.045; 95% confidence interval: 1.023, 7.398). Although a number of mediating variables (beliefs about ART, coping style, social support, and goals set) had statistically significant changes in the expected direction in the MI group compared with controls, in the intent-to-treat analysis, the mean adherence at study exit for the intervention group was 76% (SD = 27%) and 71% (SD = 27%) for the control group (P = 0.62).
conclusionAlthough not definitive, this study provides some evidence that MI offers an effective approach to improving adherence. Future studies able to build MI into the intervention for longer than 3 months may have a greater impact.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.