ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Muscarinic enhancement of R-type calcium currents in hippocampal CA1 pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Interictal quantitative EEG in migraine: a blinded controlled study.The journal of headache and pain · 2009Trial
- Cholinergic regulation of dendritic CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Revealing the complex role of CDKL5 in developmental epilepsy through a calcium channel related vision.Acta epileptologica · 2024Article
- Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.Nature communications · 2023Article
- CaInternational journal of molecular sciences · 2022Review
- Breeding of CaScientific reports · 2021Article
- Enhanced hippocampal type II theta activity AND altered theta architecture in mice lacking the CaScientific reports · 2021Article
- A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition.Hippocampus · 2019Article
- Dual Regulation of R-Type CaV2.3 Channels by M1 Muscarinic Receptors.Molecules and cells · 2016Article
- Review: CaThe open neurology journal · 2016Article
- Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Altered theta oscillations and aberrant cortical excitatory activity in the 5XFAD model of Alzheimer's disease.Neural plasticity · 2015Article
- Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- How "Pharmacoresistant" is Cav2.3, the Major Component of Voltage-Gated R-type Ca2+ Channels?Pharmaceuticals (Basel, Switzerland) · 2013Article
- Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Synergistic actions of metabotropic acetylcholine and glutamate receptors on the excitability of hippocampal CA1 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels.The Journal of general physiology · 2012Article
- Article
- The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current.The Journal of general physiology · 2009Article
- Orientation of palmitoylated CaVbeta2a relative to CaV2.2 is critical for slow pathway modulation of N-type Ca2+ current by tachykinin receptor activation.The Journal of general physiology · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "toxin-resistant" R-type Ca2+ channels are expressed widely in the CNS and distributed mainly in apical dendrites and spines. They play important roles in regulating signal transduction and intrinsic properties of neurons, but the modulation of these channels in the mammalian CNS has not been studied. In this study we used whole-cell patch-clamp recordings and found that muscarinic activation enhances R-type, but does not affect T-type, Ca2+ currents in hippocampal CA1 pyramidal neurons after N, P/Q, and L-type Ca2+ currents selectively were blocked. M1/M3 cholinergic receptors mediated the muscarinic stimulation of R-type Ca2+ channels. The signaling pathway underlying the R-type enhancement was independent of intracellular [Ca2+] changes and required the activation of a Ca(2+)-independent PKC pathway. Furthermore, we found that the enhancement of R-type Ca2+ currents resulted in the de novo appearance of Ca2+ spikes and in remarkable changes in the firing pattern of R-type Ca2+ spikes, which could fire repetitively in the theta frequency. Therefore, muscarinic enhancement of R-type Ca2+ channels could play an important role in modifying the dendritic response to synaptic inputs and in the intrinsic resonance properties of neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.