ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 102 citations in OpenAlex.
- An anatomical and physiological basis for flexible coincidence detection in the auditory system.eLife · 2025Article
- CaBP1 and 2 enable sustained CaeLife · 2024Article
- Bile Acid Application in Cell-Targeting for Molecular Receptors in Relation to Hearing: A Comprehensive Review.Current drug targets · 2024Review
- Hyperacusis in the AdultInternational journal of molecular sciences · 2023Article
- Small molecule modulation of the large-conductance calcium-activated potassium channel suppresses salicylate-induced tinnitus in mice.Frontiers in neuroscience · 2022Article
- Noise-Induced Hearing Loss in Gerbil: Round Window Assays of Synapse Loss.Frontiers in cellular neuroscience · 2021Article
- Synaptic Release Potentiation at Aging Auditory Ribbon Synapses.Frontiers in aging neuroscience · 2021Article
- Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells.Faculty reviews · 2020Review
- MRI detection of endolymphatic hydrops in Meniere's disease in 8 minutes using MIIRMR and a 20-channel coil after targeted gadolinium delivery.World journal of otorhinolaryngology - head and neck surgery · 2019Article
- LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Screening of noise-induced hearing loss (NIHL)-associated SNPs and the assessment of its genetic susceptibility.Environmental health : a global access science source · 2019Article
- Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.Scientific reports · 2019Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus.Scientific reports · 2017Article
- Presynaptic BK channels control transmitter release: physiological relevance and potential therapeutic implications.The Journal of physiology · 2016Review
- Towards a Diagnosis of Cochlear Neuropathy with Envelope Following Responses.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Plasticity in ion channel expression underlies variation in hearing during reproductive cycles.Current biology : CB · 2013Article
- Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea.Journal of neurophysiology · 2013Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Large-conductance voltage- and Ca(2+)-activated K+ channels (BKCa) are involved in shaping spiking patterns in many neurons. Less is known about their role in mammalian inner hair cells (IHCs), mechanosensory cells with unusually large BKCa currents. These currents may be involved in shaping the receptor potential, implying crucial importance for the properties of afferent auditory signals. We addressed the function of BKCa by recording sound-induced responses of afferent auditory nerve (AN) fibers from mice with a targeted deletion of the pore-forming alpha-subunit of BKCa (BKalpha(-/-)) and comparing these with voltage responses of current-clamped IHCs. BKCa-mediated currents in IHCs were selectively abolished in BKalpha(-/-), whereas cochlear physiology was essentially normal with respect to cochlear sensitivity and frequency tuning.BKalpha(-/-) AN fibers showed deteriorated precision of spike timing, measured as an increased variance of first spike latency in response to tone bursts. This impairment could be explained by a slowed voltage response in the presynaptic IHC resulting from the reduced K+ conductance in the absence of BKCa. Maximum spike rates of AN fibers were reduced nearly twofold in BKalpha(-/-), contrasting with increased voltage responses of IHCs. In addition to presynaptic changes, which may be secondary to a modest depolarization of BKalpha(-/-) IHCs, this reduction in AN rates suggests a role of BKCa in postsynaptic AN neurons, which was supported by increased refractory periods. In summary, our results indicate an essential role of IHC BKCa channels for precise timing of high-frequency cochlear signaling as well as a function of BKCa in the primary afferent neuron.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.