ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 124 citations in OpenAlex.
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- Slow ion concentration oscillations and multiple states in neuron-glia interaction-insights gained from reduced mathematical models.Frontiers in network physiology · 2023Article
- Focal seizures are organized by feedback between neural activity and ion concentration changes.eLife · 2022Article
- Modeling of sustained spontaneous network oscillations of a sexually dimorphic brainstem nucleus: the role of potassium equilibrium potential.Journal of computational neuroscience · 2021Article
- Comodulation of h- and NaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mutual Interactions between Brain States and Alzheimer's Disease Pathology: A Focus on Gamma and Slow Oscillations.Biology · 2021Review
- Interstitial ions: A key regulator of state-dependent neural activity?Progress in neurobiology · 2020Review
- Dynamics of a neuron-glia system: the occurrence of seizures and the influence of electroconvulsive stimuli : A mathematical and numerical study.Journal of computational neuroscience · 2020Article
- Immediate versus delayed control demands elicit distinct mechanisms for instantiating proactive control.Cognitive, affective & behavioral neuroscience · 2019Article
- Local Gamma Activity During Non-REM Sleep in the Context of Sensory Evoked K-Complexes.Frontiers in neuroscience · 2019Article
- Efficient Implementation of Cerebellar Purkinje Cell With the CORDIC Algorithm on LaCSNN.Frontiers in neuroscience · 2019Article
- Astrocytic modulation of cortical oscillations.Scientific reports · 2018Article
- Origin of slow spontaneous resting-state neuronal fluctuations in brain networks.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Switchable slow cellular conductances determine robustness and tunability of network states.PLoS computational biology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Little is known about the dynamics and mechanisms of transitions between tonic firing and bursting in cortical networks. Here, we use a computational model of a neocortical circuit with extracellular potassium dynamics to show that activity-dependent modulation of intrinsic excitability can lead to sustained oscillations with slow transitions between two distinct firing modes: fast run (tonic spiking or fast bursts with few spikes) and slow bursting. These transitions are caused by a bistability with hysteresis in a pyramidal cell model. Balanced excitation and inhibition stabilizes a network of pyramidal cells and inhibitory interneurons in the bistable region and causes sustained periodic alternations between distinct oscillatory states. During spike-wave seizures, neocortical paroxysmal activity exhibits qualitatively similar slow transitions between fast run and bursting. We therefore predict that extracellular potassium dynamics can cause alternating episodes of fast and slow oscillatory states in both normal and epileptic neocortical networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.