ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Gsalpha is involved in sugar perception in Drosophila melanogaster.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 64 citations in OpenAlex.
- Comparative experience shapes sucrose preference through memory in Drosophila.Molecular brain · 2025Article
- Hawkmoth Pheromone Transduction Involves G-Protein-Dependent Phospholipase Cβ Signaling.eNeuro · 2025Article
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- Decoding bee cleptoparasitism through comparative transcriptomics of Coelioxoides waltheriae and its host Tetrapedia diversipes.Scientific reports · 2024Article
- Tastant-receptor interactions: insights from the fruit fly.Frontiers in nutrition · 2024Review
- Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila.Disease models & mechanisms · 2023Article
- Review
- Confection Confusion: Interplay Between Diet, Taste, and Nutrition.Trends in endocrinology and metabolism: TEM · 2021Review
- Temperature and Sweet Taste Integration in Drosophila.Current biology : CB · 2020Article
- Membrane Proteins Mediating Reception and Transduction in Chemosensory Neurons in Mosquitoes.Frontiers in physiology · 2018Review
- A Drosophila ex vivo model of olfactory appetitive learning.Scientific reports · 2017Article
- Effects of age and nutritional state on the expression of gustatory receptors in the honeybee (Apis mellifera).PloS one · 2017Article
- Molecular neurobiology of Drosophila taste.Current opinion in neurobiology · 2015Review
- Article
- Molecular Cloning and Characterization of G Alpha Proteins from the Western Tarnished Plant Bug, Lygus hesperus.Insects · 2014Article
- Peripheral coding of taste.Neuron · 2014Review
- Neural mechanisms of alarm pheromone signaling.Molecules and cells · 2013Review
- Gαo is required for L-canavanine detection in Drosophila.PloS one · 2013Article
- Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals.PLoS genetics · 2012Article
- Sugar-regulated cation channel formed by an insect gustatory receptor.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Drosophila melanogaster, gustatory receptor genes (Grs) encode G-protein-coupled receptors (GPCRs) in gustatory receptor neurons (GRNs) and some olfactory receptor neurons. One of the Gr genes, Gr5a, encodes a sugar receptor that is expressed in a subset of GRNs and has been most extensively studied both molecularly and physiologically, but the G-protein alpha subunit (Galpha) that is coupled to this sugar receptor remains unknown. Here, we propose that Gs is the Galpha that is responsible for Gr5a-mediated sugar-taste transduction, based on the following findings: First, immunoreactivities against Gs were detected in a subset of GRNs including all Gr5a-expressing neurons. Second, trehalose-intake is reduced in flies heterozygous for null mutations in DGsalpha, a homolog of mammalian Gs, and trehalose-induced electrical activities in sugar-sensitive GRNs were depressed in those flies. Furthermore, expression of wild-type DGsalpha in sugar-sensitive GRNs in heterozygotic DGsalpha mutant flies rescued those impairments. Third, expression of double-stranded RNA for DGsalpha in sugar-sensitive GRNs depressed both behavioral and electrophysiological responses to trehalose. Together, these findings indicate that DGsalpha is involved in trehalose perception. We suggest that sugar-taste signals are processed through the Gsalpha-mediating signal transduction pathway in sugar-sensitive GRNs in Drosophila.
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