ArticleBMC infectious diseases2006
More men than women make mucosal IgA antibodies to Human papillomavirus type 16 (HPV-16) and HPV-18: a study of oral HPV and oral HPV antibodies in a normal healthy population.
Article in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Prevalence of oral HPV infection and genotype distribution in Iranian children during the early ages of life.Virology journal · 2025Article
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- Seroprevalence of mucosal and cutaneous human papillomavirus (HPV) types among children and adolescents in the general population in Germany.BMC infectious diseases · 2022Article
- Oral and oropharyngeal high-risk HPV prevalence, HIV status, and risk behaviours in a cohort of South African men who have sex with men.AIMS public health · 2022Article
- Human Papillomavirus Prevalence in Oral and Oropharyngeal Rinse and Gargle Specimens of Dental Patients and of an HIV-Positive Cohort from Pretoria, South Africa.Advances in virology · 2020Article
- Evaluation of HPV-16 and HPV-18 specific antibody measurements in saliva collected in oral rinses and merocel® sponges.Vaccine · 2018Article
- Prevalence and Determinants of Oral Human Papillomavirus Infection in 500 Young Adults from Italy.PloS one · 2017Article
- Human papillomavirus vaccination induces neutralising antibodies in oral mucosal fluids.British journal of cancer · 2016Article
- Article
- Behavioral, immunologic, and virologic correlates of oral human papillomavirus infection in HIV-infected youth.Sexually transmitted diseases · 2015Observational
- Lessons learned from successful human vaccines: Delineating key epitopes by dissecting the capsid proteins.Human vaccines & immunotherapeutics · 2015Review
- Screening and detection of human papillomavirus (HPV) high-risk strains HPV16 and HPV18 in saliva samples from subjects under 18 years old in Nevada: a pilot study.BMC oral health · 2012Article
- Distribution of human papillomavirus genotypes in sardinian patients with oral squamous cell carcinoma.The open virology journal · 2010Article
- Bogarting that joint might decrease oral HPV among cannabis users.Current oncology (Toronto, Ont.) · 2009Article
- Antibody responses in oral fluid after administration of prophylactic human papillomavirus vaccines.The Journal of infectious diseases · 2009Article
- Development and validation of a HPV-32 specific PCR assay.Virology journal · 2009Article
- Human papillomavirus-related diseases: oropharynx cancers and potential implications for adolescent HPV vaccination.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2008Review
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have previously shown the high prevalence of oral anti-human papillomavirus type 16 (HPV-16) antibodies in women with HPV-associated cervical neoplasia. It was postulated that the HPV antibodies were initiated after HPV antigenic stimulation at the cervix via the common mucosal immune system. The present study aimed to further evaluate the effectiveness of oral fluid testing for detecting the mucosal humoral response to HPV infection and to advance our limited understanding of the immune response to HPV.
methodsThe prevalence of oral HPV infection and oral antibodies to HPV types 16, 18 and 11 was determined in a normal, healthy population of children, adolescents and adults, both male and female, attending a dental clinic. HPV types in buccal cells were determined by DNA sequencing. Oral fluid was collected from the gingival crevice of the mouth by the OraSure method. HPV-16, HPV-18 and HPV-11 antibodies in oral fluid were detected by virus-like particle-based enzyme-linked immunosorbent assay. As a reference group 44 women with cervical neoplasia were included in the study.
resultsOral HPV infection was highest in children (9/114, 7.9%), followed by adolescents (4/78, 5.1%), and lowest in normal adults (4/116, 3.5%). The predominant HPV type found was HPV-13 (7/22, 31.8%) followed by HPV-32 (5/22, 22.7%). The prevalence of oral antibodies to HPV-16, HPV-18 and HPV-11 was low in children and increased substantially in adolescents and normal adults. Oral HPV-16 IgA was significantly more prevalent in women with cervical neoplasia (30/44, 68.2%) than the women from the dental clinic (18/69, 26.1% P = 0.0001). Significantly more adult men than women displayed oral HPV-16 IgA (30/47 compared with 18/69, OR 5.0, 95% CI 2.09-12.1, P < 0.001) and HPV-18 IgA (17/47 compared with 13/69, OR 2.4, 95% CI 0.97-6.2, P = 0.04).
conclusionThe increased prevalence of oral HPV antibodies in adolescent individuals compared with children was attributed to the onset of sexual activity. The increased prevalence of oral anti-HPV IgA in men compared with women was noteworthy considering reportedly fewer men than women make serum antibodies, and warrants further investigation.
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