ArticleThe Journal of general virology2006
Reduced ability of newborns to produce CCL3 is associated with increased susceptibility to perinatal human immunodeficiency virus 1 transmission.
Article in The Journal of general virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Pooled it
- Low maternal viral loads and reduced granulocyte-macrophage colony-stimulating factor levels characterize exposed, uninfected infants who develop protective human immunodeficiency virus type 1-specific responses.Clinical and vaccine immunology : CVI · 2007Trial
- Reduced CCR5 Expression and Immune Quiescence in Black South African HIV-1 Controllers.Frontiers in immunology · 2021Article
- Perspective: DNA Copy Number Variations in Cardiovascular Diseases.Epigenetics insights · 2018Review
- Host Molecular Factors and Viral Genotypes in the Mother-to-Child HIV-1 Transmission in Sub-Saharan Africa.Journal of public health in Africa · 2017Review
- Complex and multi-allelic copy number variation in human disease.Briefings in functional genomics · 2015Review
- Host factors and early treatments to restrict paediatric HIV infection and early disease progression.Journal of virus eradication · 2015Review
- Healthy Neonates Possess a CD56-Negative NK Cell Population with Reduced Anti-Viral Activity.PloS one · 2013Article
- Influence of intragenic CCL3 haplotypes and CCL3L copy number in HIV-1 infection in a sub-Saharan African population.Genes and immunity · 2013Article
- Upregulation of innate antiviral restricting factor expression in the cord blood and decidual tissue of HIV-infected mothers.PloS one · 2013Article
- CCL3L1 gene copy number in individuals with and without HIV-associated neurocognitive disorder.Current biomarker findings · 2012Article
- HIV-1 co-receptor usage: influence on mother-to-child transmission and pediatric infection.Journal of translational medicine · 2011Review
- Host factors that influence mother-to-child transmission of HIV-1: genetics, coinfections, behavior and nutrition.Future virology · 2011Article
- Copy number variation in chemokine superfamily: the complex scene of CCL3L-CCL4L genes in health and disease.Clinical and experimental immunology · 2010Review
- Variations in CCL3L gene cluster sequence and non-specific gene copy numbers.BMC research notes · 2010Article
- Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases.Genes and immunity · 2010Article
- CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users.The Journal of infectious diseases · 2010Article
- A whole genome association study of mother-to-child transmission of HIV in Malawi.Genome medicine · 2010Article
- Functional genetic variants in DC-SIGNR are associated with mother-to-child transmission of HIV-1.PloS one · 2009Article
- Host genetic determinants of human immunodeficiency virus infection and disease progression in children.Pediatric research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The role of CC chemokines in protection against mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission is not well understood. It was observed that mitogen-induced production of CCL3 and CCL4 by cord-blood mononuclear cells was increased among infants born to HIV-positive compared with HIV-negative mothers, and that a deficiency in production of CCL3 was associated with increased susceptibility to intrapartum HIV-1 infection. CCL3-L1 gene copy number was associated with CCL3 production and with vertical transmission. However, at equivalent CCL3-L1 gene copy numbers, infants who acquired HIV-1 infection relative to their exposed but uninfected counterparts had lower production of CCL3, suggesting that they may harbour some non-functional copies of this gene. Nucleotide changes that may influence CCL3 production were evident in the CCL3 and CCL3-L1 genes upstream of exon 2. Our findings suggest that infants who display a deficient-production phenotype of CCL3 are at increased risk of acquiring HIV-1, indicating that this chemokine in particular plays an essential role in protective immunity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.