ArticleJournal of neurophysiology2006
Creation and reduction of a morphologically detailed model of a leech heart interneuron.
Article in Journal of neurophysiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
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- Neuronal morphology enhances robustness to perturbations of channel densities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Data-driven reduction of dendritic morphologies with preserved dendro-somatic responses.eLife · 2021Article
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- Degeneracy in hippocampal physiology and plasticity.Hippocampus · 2019Review
- Distinct current modules shape cellular dynamics in model neurons.Neuroscience · 2016Article
- Automated evolutionary optimization of ion channel conductances and kinetics in models of young and aged rhesus monkey pyramidal neurons.Journal of computational neuroscience · 2016Article
- Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron.PLoS computational biology · 2015Article
- Analogous synaptic plasticity profiles emerge from disparate channel combinations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Development of modified cable models to simulate accurate neuronal active behaviors.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- The role of linear and voltage-dependent ionic currents in the generation of slow wave oscillations.Journal of computational neuroscience · 2014Article
- Using Strahler's analysis to reduce up to 200-fold the run time of realistic neuron models.Scientific reports · 2013Article
- Correlated conductance parameters in leech heart motor neurons contribute to motor pattern formation.PloS one · 2013Article
- Inactivating ion channels augment robustness of subthreshold intrinsic response dynamics to parametric variability in hippocampal model neurons.The Journal of physiology · 2012Article
- Fast and accurate low-dimensional reduction of biophysically detailed neuron models.Scientific reports · 2012Article
- The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites.Journal of computational neuroscience · 2011Article
- How does maintenance of network activity depend on endogenous dynamics of isolated neurons?Neural computation · 2009Article
- Signal propagation in Drosophila central neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Conductance-based neuron models aid in understanding the role intrinsic and synaptic currents play in producing neuronal activity. Incorporating morphological detail into a model allows for additional analysis of nonhomogeneous distributions of active and synaptic conductances, as well as spatial segregation of electrical events. We developed a morphologically detailed "Full Model" of a leech heart interneuron that replicates reasonably well intracellular recordings from these interneurons. However, it constitutes hundreds of compartments, each increasing parameter space and simulation time. To reduce the number of compartments of the Full Model, while preserving conductance densities and distributions, its compartments were grouped into functional groups that each share identical conductance densities. Each functional group was sequentially reduced to one or two compartments, preserving surface area, conductance densities, and its contribution to input resistance. As a result, the input resistance and membrane time constant were preserved. The axial resistances of several compartments were rescaled to match the amplitude of synaptic currents and low-threshold calcium currents and the shape of action potentials to those in the Full Model. This reduced model, with intrinsic conductances, matched the activity of the Full Model for a variety of simulated current-clamp and voltage-clamp data. Because surface area and conductance distribution of the functional groups of the Full Model were maintained, parameter changes introduced into the reduced model can be directly translated to the Full Model. Thus our computationally efficient reduced morphology model can be used as a tool for exploring the parameter space of the Full Model and in network simulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.