Evidence map›Paper›PMID 16759992›Full record

ArticleEnvironmental health perspectives2006

PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract.

Risheng Ma, David A Sassoon

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature.International journal of environmental research and public health · 2017
    Review
  11. Article
  12. Review
  13. Methodological issues in human studies of endocrine disrupting chemicals.Reviews in endocrine & metabolic disorders · 2015
    Review
  14. Article
  15. Metabolism and metabolites of polychlorinated biphenyls.Critical reviews in toxicology · 2015
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Risheng MaBrookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai Medical School, New York, New York, USA.
David A Sassoon

Funding

URBAN HEAVY METAL EXPOSURE--ELEMENTAL AND ISOTOPIC COMPOSITION OF SAMPLESP42ES007384 · NIEHS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI LANDRIGAN, PHILIP J · 1995 to 2006
$8.0M
Molecular basis of uterine cellular interactionsR01CA112686 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SASSOON, DAVID A · 2004 to 2008
$1.5M
NCI NIH HHS R01 CA112686NCI NIH HHS R01CA112686NIEHS NIH HHS P42 ES007384NIEHS NIH HHS P42 ES07384
6 · The paper itself

Abstract

Polychlorinated biphenyls (PCBs) have been proposed to have a weak estrogenic activity and therefore pose a risk as potential environmental endocrine disruptors to the perinatal development of the female reproductive tract. Perinatal exposure to high concentrations of the potent synthetic estrogen diethylstilbestrol (DES) induces abnormal development of the female reproductive tract via a mechanism that acts through the down-regulation of Wnt7a (wingless-type MMTV integration site family, member 7A). To test the hypothesis that PCBs act as weak estrogens, we injected neonatal mice with a commercial PCB mixture (Aroclor 1254) or with low levels of DES and measured effects of exposure on Wnt7a expression and uterine morphology. We report here that neonatal PCB or low-level DES exposure resulted in the down-regulation of Wnt7a expression. In addition, both PCB and low-level DES exposure induced changes in the uterine myometrium and gland formation. These data reveal that weak estrogens such as the PCBs act through a Wnt7a-dependent pathway and suggest that Wnt7a regulation is a sensitive biomarker for testing weak estrogenic candidate compounds. The morphologic changes that were elicited by PCBs and DES were different immediately after exposure, suggesting that Wnt7a-independent pathways are also activated by one or both of these compounds. Although Wnt7a down-regulation is transient after estrogenic exposure, subsequent morphologic changes became more pronounced during postnatal and adult life, suggesting that the female reproductive tract is permanently reprogrammed after exposure even to weak estrogenic compounds. In addition, Wnt7a heterozygous mice were more sensitive to PCB exposure, revealing an important genetic predisposition to risks of environmental endocrine disruptors.

Indexed as

AnimalsAroclorsDiethylstilbestrolEndocrine DisruptorsEstrogensFemaleHeterozygoteMicePolychlorinated BiphenylsProto-Oncogene ProteinsSignal TransductionWnt ProteinsAroclorsDiethylstilbestrolEndocrine DisruptorsEstrogensPolychlorinated BiphenylsProto-Oncogene ProteinsWnt7a protein, mouseWnt Proteins

Identifiers

PMID16759992
PMCPMC1480489
OpenAlexW1974897134

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.