ArticleEnvironmental health perspectives2006
Activation of the stress axis and neurochemical alterations in specific brain areas by concentrated ambient particle exposure with concomitant allergic airway disease.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 86 citations in OpenAlex.
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- Dysregulated metabolic pathways associated with air pollution exposure and the risk of autism: Evidence from epidemiological studies.Environmental pollution (Barking, Essex : 1987) · 2024Review
- Association between prenatal and childhood PMEnvironmental epidemiology (Philadelphia, Pa.) · 2024Article
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells.International journal of molecular sciences · 2022Article
- Noise as a cause of neurodegenerative disorders: molecular and cellular mechanisms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- PMInnovation (Cambridge (Mass.)) · 2022Article
- Ambient air pollutants are associated with morning serum cortisol in overweight and obese Latino youth in Los Angeles.Environmental health : a global access science source · 2021Article
- Hypothalamic-pituitary-adrenal axis mediates ambient PMEcotoxicology and environmental safety · 2021Article
- Air pollution is associated with elevated HPA-Axis response to stress in anxious adolescent girls.Comprehensive psychoneuroendocrinology · 2020Article
- Depression in the house: The effects of household air pollution from solid fuel use among the middle-aged and older population in China.The Science of the total environment · 2020Article
- Susceptibility Variations in Air Pollution Health Effects: Incorporating Neuroendocrine Activation.Toxicologic pathology · 2019Article
- The cross-sectional and longitudinal association between air pollution and salivary cortisol: Evidence from the Multi-Ethnic Study of Atherosclerosis.Environment international · 2019Article
- Association between ambient PMThe American journal of emergency medicine · 2019Observational
- Air Pollution Exposure and Cognitive Function in Taiwanese Older Adults: A Repeated Measurement Study.International journal of environmental research and public health · 2019Article
- Do exposure to outdoor temperatures, NOBMJ open · 2019Article
- The Association between Long-Term Air Pollution and Urinary Catecholamines: Evidence from the Multi-Ethnic Study of Atherosclerosis.Environmental health perspectives · 2019Article
- Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts.Journal of Alzheimer's disease : JAD · 2019Review
- Fungal biotransformation of synthetic levodopa to stable dopamine in l-ascorbate-mediated aerobic-thermophilic biochemical process.3 Biotech · 2018Article
- Chronic exposure to inhaled, traffic-related nitrogen dioxide and a blunted cortisol response in adolescents.Environmental research · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveExposure to ambient particulate matter (PM) has been linked to respiratory diseases in people living in urban communities. The mechanism by which PM produces these diseases is not clear. We hypothesized that PM could act on the brain directly to stimulate the stress axis and predispose individuals to these diseases. The purpose of this study was to test if exposure to PM can affect brain areas involved in the regulation of neuroendocrine functions, especially the stress axis, and to study whether the presence of preexisting allergic airway disease aggravates the stress response.
designAdult male rats (n = 8/group) with or without ovalbumin (OVA)-induced allergic airway disease were exposed to concentrated air particles containing PM with an aerodynamic diameter pound 2.5 microm (PM(2.5)) for 8 hr, generated from ambient air in an urban Grand Rapids, Michigan, community using a mobile air research laboratory (AirCARE 1). Control animals were exposed to normal air and were treated with saline. MEASUREMENTS: A day after PM(2.5) exposure, animals were sacrificed and the brains were removed, frozen, and sectioned. The paraventricular nucleus (PVN) and other brain nuclei were microdissected, and the concentrations of aminergic neurotransmitters and their metabolites were measured using high-performance liquid chromatography with electrochemical detection. Serum corticosterone levels were measured using radioimmunoassay.
resultsA significant increase in the concentration (mean +/- SE, pg/microg protein) of norepinephrine in the PVN was produced by exposure to concentrated ambient particles (CAPs) or OVA alone (12.45 +/- 2.7 and 15.84 +/- 2.8, respectively) or after sensitization with OVA (19.06 +/- 3.8) compared with controls (7.98 +/- 1.3 ; p < 0.05). Serum corticosterone (mean +/- SE, ng/mL) was significantly elevated in the OVA + CAPs group (242.786 +/- 33.315) and in the OVA-presensitized group (242.786 +/- 33.315) compared with CAP exposure alone (114.55 +/- 20.9). Exposure to CAPs (alone or in combination with OVA pretreatment) can activate the stress axis, and this could probably play a role in aggravating allergic airway disease.
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