ArticleCroatian medical journal2006
Pharmacotherapy of treatment-resistant combat-related posttraumatic stress disorder with psychotic features.
Article in Croatian medical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Interventions for adults with a history of complex traumatic events: the INCiTE mixed-methods systematic review.Health technology assessment (Winchester, England) · 2020Pooled it
- Quetiapine Treatment for Post-traumatic Stress Disorder: A Systematic Review of the Literature.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2023Review
- Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans.Biomolecules · 2021Article
- N-glycomic Profile in Combat Related Post-Traumatic Stress Disorder.Biomolecules · 2019Article
- Posttraumatic stress disorder with secondary psychotic features (PTSD-SP): Diagnostic and treatment challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Circulating levels of hormones, lipids, and immune mediators in post-traumatic stress disorder - a 3-month follow-up study.Frontiers in psychiatry · 2015Article
- Predictors of premature discontinuation of outpatient treatment after discharge of patients with posttraumatic stress disorder.Neuropsychiatric disease and treatment · 2015Article
- A diagnostic dilemma between psychosis and post-traumatic stress disorder: a case report and review of the literature.Journal of medical case reports · 2011Article
- Heterogeneity of posttraumatic stress disorder symptoms in Croatian war veterans: retrospective study.Croatian medical journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess retrospectively the clinical effects of typical (fluphenazine) or atypical (olanzapine, risperidone, quetiapine) antipsychotics in three open clinical trials in male Croatian war veterans with chronic combat-related posttraumatic stress disorder (PTSD) with psychotic features, resistant to previous antidepressant treatment.
methodsInpatients with combat-related PTSD were treated for 6 weeks with fluphenazine (n=27), olanzapine (n=28), risperidone (n=26), or quetiapine (n=53) as a monotherapy. Treatment response was assessed by the reduction in total and subscales scores in the clinical scales measuring PTSD (PTSD interview and Clinician-administered PTSD Scale) and psychotic symptoms (Positive and Negative Syndrome Scale).
resultsAfter 6 weeks of treatment, monotherapy with fluphenazine, olanzapine, risperidone, or quetiapine in patients with PTSD significantly decreased the scores listed in trauma reexperiencing, avoidance, and hyperarousal subscales in the clinical scales measuring PTSD, and total and subscales scores listed in positive, negative, general psychopathology, and supplementary items of the Positive and Negative Syndrome Scale subscales, respectively (P<0.001).
conclusionPTSD and psychotic symptoms were significantly reduced after monotherapy with typical or atypical antipsychotics. As psychotic symptoms commonly occur in combat-related PTSD, the use of antipsychotic medication seems to offer another approach to treat a psychotic subtype of combat-related PTSD resistant to previous antidepressant treatment.
Indexed as
Identifiers
16758523PMC2080433W2170834410What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.