ArticleCroatian medical journal2006
Mutations in Helicobacter pylori porD and oorD genes may contribute to furazolidone resistance.
Article in Croatian medical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Safety of furazolidone-containing regimen inBMJ open · 2020Pooled it
- Furazolidone-based therapies for Helicobacter pylori infection: a pooled-data analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Trial
- Antibiotic resistance in Helicobacter pylori: a genetic and physiological perspective.Gut pathogens · 2025Review
- Furazolidone susceptibility of Helicobacter pylori isolated from patients with gastroduodenal diseases in Colombia.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Point Mutations in Furazolidone and Rifampicin Resistance Genes inAntibiotics (Basel, Switzerland) · 2024Article
- Exploring Alternative Treatment Choices for Multidrug-Resistant Clinical Strains ofMicroorganisms · 2023Article
- Antibiotic resistance in Helicobacter pylori: From potential biomolecular mechanisms to clinical practice.Journal of clinical laboratory analysis · 2023Review
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- Helicobacter pylori infection and antibiotic resistance - from biology to clinical implications.Nature reviews. Gastroenterology & hepatology · 2021Review
- A retrospective study of the antibiotic-resistant phenotypes and genotypes ofAmerican journal of cancer research · 2021Article
- The Involvement of theFrontiers in cellular and infection microbiology · 2018Article
- Resistance ofWorld journal of gastroenterology · 2017Article
- Primary Antibiotic Resistance of Helicobacter pylori in China.Digestive diseases and sciences · 2017Review
- Novel and Effective Therapeutic Regimens forFrontiers in cellular and infection microbiology · 2017Review
- The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
- Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china.Current microbiology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the rate of furazolidone resistance of Helicobacter pylori (H. pylori) isolated from gastric biopsy specimens and to explore the relationship between genetic mutations in porD and oorD genes of H. pylori and its resistance to the antibiotic.
methodsGastric biopsy was performed in 83 adult patients aged 31-77 years with gastric complaints. H. pylori was isolated from biopsy specimens of 46 patients. E-test and 2-fold agar dilution method were used to determine the rate of H. pylori resistance to furazolidone. The genes porD and oorD from susceptible and resistant isolates were amplified by polymerase chain reaction (PCR), and their PCR products were sequenced.
resultsResistance to furazolidone was found in 8.7% of H. pylori isolates and 6 mutations were detected in porD and oorD genes of the resistant isolates. Three mutations--G353A, A356G, and C357T--occurred in porD and the other mutations--A041G, A122G, C349A(G)--occurred in oorD genes.
conclusionsChanges in 6 amino acids may be associated with the resistance of H. pylori to furazolidone.
Indexed as
Identifiers
16758519PMC2080422W2123166258What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.